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Comparison of Gamma-Ray-Induced Chromosome Ring and Inversion Frequencies

A method was used to detect chromosome inversions as apparent or false sister chromatid exchanges (SCEs) in the first mitosis after γ irradiation of human G0 cells. Dose-response relationships for small inversions have not been measured and reported previously, but it has been assumed that these are...

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Published in:	Radiation research 1995-08, Vol.143 (2), p.175-180
Main Authors:	Mühlmann-Díaz, María C., Bedford, Joel S.
Format:	Article
Language:	English
Subjects:	Biological and medical sciences Cell cycle Cell Line Cell physiology CHO cells Chromatids Chromosome Inversion Chromosomes Cultured cells Effects of physical and chemical agents Fundamental and applied biological sciences. Psychology Gamma Rays Humans Ionizing radiation Irradiation Lymphocytes Mitosis Molecular and cellular biology Radiation dosage Resting Phase, Cell Cycle - radiation effects Ring Chromosomes Sister Chromatid Exchange Space life sciences
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container_title	Radiation research
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creator	Mühlmann-Díaz, María C. Bedford, Joel S.
description	A method was used to detect chromosome inversions as apparent or false sister chromatid exchanges (SCEs) in the first mitosis after γ irradiation of human G0 cells. Dose-response relationships for small inversions have not been measured and reported previously, but it has been assumed that these are induced with a frequency equal to that of their easily measured asymmetrical counterpart, the interstitial deletion. Our experiments confirm this expectation. The results also demonstrate, as others have suggested, that in protocols where SCEs have been reported in the first postirradiation mitosis after incorporation of BrdU in the previous cell cycle, the X- or γ-ray treatment of G0- or G1-phase cells produces virtually no true SCEs.
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Psychology</subject><subject>Gamma Rays</subject><subject>Humans</subject><subject>Ionizing radiation</subject><subject>Irradiation</subject><subject>Lymphocytes</subject><subject>Mitosis</subject><subject>Molecular and cellular biology</subject><subject>Radiation dosage</subject><subject>Resting Phase, Cell Cycle - radiation effects</subject><subject>Ring Chromosomes</subject><subject>Sister Chromatid Exchange</subject><subject>Space life sciences</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNp1kFFLwzAUhYMoc07xFwh9EH2qJr1J0zxKcbMwEIY-lyxJtaNpZrIK-_dGVuaTT5fL-e49nIPQNcEPGWD-CIwLwugJmhIBRcoopqdoijFAylnBz9FFCBscd5KLCZrwHAgmeIqq0tmt9G1wfeKaZCGtlelK7tOq14MyOik_vbMuOGuSVdt_JLLXSdV_Gx_aeDL35mswvWpNuERnjeyCuRrnDL3Pn9_Kl3T5uqjKp2WqIMe7lGFtOCU5sDWjWaYEF1LlosEaMsMkzTQX0GhgDEsGhco4xdxIKg3ggsW7Gbo7_N16F73DrrZtUKbrZG_cEGrOKbACSATvD6DyLgRvmnrrWyv9via4_i2tHkuL5M34clhbo4_c2FLUb0ddBiW7xsuYOBwxiGEEsD9sE3bO_-v2A2X4fEo</recordid><startdate>19950801</startdate><enddate>19950801</enddate><creator>Mühlmann-Díaz, María C.</creator><creator>Bedford, Joel S.</creator><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950801</creationdate><title>Comparison of Gamma-Ray-Induced Chromosome Ring and Inversion Frequencies</title><author>Mühlmann-Díaz, María C. ; Bedford, Joel S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-50de741635b5422c979ac69f0d32e5a42d793fd3550a538c27407ea4ae3085163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Biological and medical sciences</topic><topic>Cell cycle</topic><topic>Cell Line</topic><topic>Cell physiology</topic><topic>CHO cells</topic><topic>Chromatids</topic><topic>Chromosome Inversion</topic><topic>Chromosomes</topic><topic>Cultured cells</topic><topic>Effects of physical and chemical agents</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gamma Rays</topic><topic>Humans</topic><topic>Ionizing radiation</topic><topic>Irradiation</topic><topic>Lymphocytes</topic><topic>Mitosis</topic><topic>Molecular and cellular biology</topic><topic>Radiation dosage</topic><topic>Resting Phase, Cell Cycle - radiation effects</topic><topic>Ring Chromosomes</topic><topic>Sister Chromatid Exchange</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mühlmann-Díaz, María C.</creatorcontrib><creatorcontrib>Bedford, Joel S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mühlmann-Díaz, María C.</au><au>Bedford, Joel S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Gamma-Ray-Induced Chromosome Ring and Inversion Frequencies</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>1995-08-01</date><risdate>1995</risdate><volume>143</volume><issue>2</issue><spage>175</spage><epage>180</epage><pages>175-180</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>A method was used to detect chromosome inversions as apparent or false sister chromatid exchanges (SCEs) in the first mitosis after γ irradiation of human G0 cells. 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subjects	Biological and medical sciences Cell cycle Cell Line Cell physiology CHO cells Chromatids Chromosome Inversion Chromosomes Cultured cells Effects of physical and chemical agents Fundamental and applied biological sciences. Psychology Gamma Rays Humans Ionizing radiation Irradiation Lymphocytes Mitosis Molecular and cellular biology Radiation dosage Resting Phase, Cell Cycle - radiation effects Ring Chromosomes Sister Chromatid Exchange Space life sciences
title	Comparison of Gamma-Ray-Induced Chromosome Ring and Inversion Frequencies
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