Anticancer drug distribution in lymph and blood during adjuvant chemotherapy after surgery for gastric carcinoma. A study with a combined preparation of 1‐(2‐tetrahydrofuryl)‐5‐fluorouracil and uracil

Previously the authors reported that the fat emulsion of 1‐(2‐tetrahydrofuryl)‐5‐fluorouracil, tegafur (FT‐207), yielded significantly higher concentrations of tegafur in the lymph and plasma compared to tegafur enteric‐coated granules (FT‐G). However, the emulsification did not improve the metaboli...

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Bibliographic Details
Published in:Cancer 1987-05, Vol.59 (9), p.1571-1576
Main Authors: Hanaue, Hitoshi, Kurosawa, Tsutomu, Kitano, Yoshiaki, Miyakawa, Sadaaki, Nemoto, Akihisa, Yamamoto, Hiroshi, Asagoe, Tatsuo, Takada, Tadahiro, Yasuda, Hideki, Shikata, Jun‐Ichi
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
Chemotherapy
Combined Modality Therapy
Drug Combinations
Fluorouracil - blood
Fluorouracil - metabolism
Humans
Lymph - metabolism
Male
Medical sciences
Metabolic Clearance Rate
Middle Aged
Pharmacology. Drug treatments
Stomach Neoplasms - drug therapy
Stomach Neoplasms - metabolism
Stomach Neoplasms - surgery
Tablets, Enteric-Coated
Tegafur - administration & dosage
Tegafur - blood
Tegafur - metabolism
Uracil - administration & dosage
Uracil - blood
Uracil - metabolism
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Summary:Previously the authors reported that the fat emulsion of 1‐(2‐tetrahydrofuryl)‐5‐fluorouracil, tegafur (FT‐207), yielded significantly higher concentrations of tegafur in the lymph and plasma compared to tegafur enteric‐coated granules (FT‐G). However, the emulsification did not improve the metabolic conversion rate of tegafur to 5‐fluorouracil (5‐FU). A study was performed to assay the plasma and lymphatic concentrations of tegafur, 5‐FU, and uracil in seven patients after radical surgery for gastric carcinoma who were given a combined oral preparation of FT‐207 and uracil (UFT). Both lymph and plasma 5‐FU levels after UFT were 20 times greater than those after FT‐G, although FT‐207 levels were not different. Patients given UFT showed significantly greater 5‐FU and uracil concentrations in the lymph compared with the plasma. The results of this study suggest a potential use of UFT as an adjuvant postoperative chemotherapeutic agent for gastric carcinoma.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19870501)59:9<1571::AID-CNCR2820590907>3.0.CO;2-9