Kaposi's Sarcoma-Associated Herpesvirus-Like DNA Sequences in Multicentric Castleman's Disease

Multicentric Castleman's disease (MCD) is an atypical lymphoproliferative disorder defined using clinical and pathologic criteria. A characteristic of the MCD is a close association with Kaposi's sarcoma (KS), which occurs during the clinical course of most human immunodeficiency virus (HI...

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Bibliographic Details
Published in:Blood 1995-08, Vol.86 (4), p.1276-1280
Main Authors: Soulier, Jean, Grollet, Laurence, Oksenhendler, Eric, Cacoub, Patrice, Cazals-Hatem, Dominique, Babinet, Paul, d'Agay, Marie-Françoise, Clauvel, Jean-Pierre, Raphael, Marline, Degos, Laurent, Sigaux, François
Format: Article
Language:English
Subjects:
Adult
Aged
AIDS/HIV
Base Sequence
Biological and medical sciences
Castleman Disease - microbiology
DNA Primers - chemistry
DNA, Viral - analysis
Female
Hematologic and hematopoietic diseases
Herpesviridae - genetics
HIV Infections - complications
Humans
Lymph Nodes - microbiology
Male
Medical sciences
Middle Aged
Molecular Sequence Data
Other diseases. Hematologic involvement in other diseases
Sarcoma, Kaposi - microbiology
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Summary:Multicentric Castleman's disease (MCD) is an atypical lymphoproliferative disorder defined using clinical and pathologic criteria. A characteristic of the MCD is a close association with Kaposi's sarcoma (KS), which occurs during the clinical course of most human immunodeficiency virus (HIV)-associated MCD cases and also, but less frequently, in HIV-negative patients. Recently, sequences of a putative new Herpesvirus (KSHV) have been isolated and further detected in almost all the acquired immunodeficiency syndrome (AIDS) KS and in most of the non-AIDS KS samples. In this study, we searched for these Herpesvirus-like sequences in MCD samples of 31 patients. KSHV sequences were detected in 14 of 14 cases of HIV-associated MCD, including 5 cases without detectable KS. Moreover, KSHV was detected in 7 of 17 MCD cases in HIV-negative patients, including 1 case associated with a cutaneous KS. In 34 non-MCD reactive lymph nodes (follicular and/or interfoliicuiar hyperplasia) in HIV-negative patients, KSHV was detected in only 1 case. In 1 HIV-negative case of MCD, KSHV was found in both the lymph node and peripheral blood samples. These data suggest that KSHV could play a role in the pathogenesis of MCD, especially in HIV-infected patients.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V86.4.1276.bloodjournal8641276