Management of systemic vasculitis: contribution of scintigraphic imaging to evaluation of disease activity and classification

The use of radio-isotope-labelled leucocyte scans has become established as a non-invasive and accurate means of diagnosing a variety of inflammatory conditions. We report a retrospective study on leucocyte imaging in the management of 50 patients with systemic vasculitis. Leucocyte imaging was usef...

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Bibliographic Details
Published in:QJM : An International Journal of Medicine 1995-07, Vol.88 (7), p.509-516
Main Authors: REUTER, H., WRAIGHT, E.P., QASIM, F.J., LOCKWOOD, C.M.
Format: Article
Language:English
Subjects:
Autoantibodies - analysis
Diagnosis, Differential
Female
Granulomatosis with Polyangiitis - diagnostic imaging
Humans
Radiography
Radionuclide Imaging
Retrospective Studies
Vasculitis - diagnostic imaging
Vasculitis - immunology
Vasculitis - pathology
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Summary:The use of radio-isotope-labelled leucocyte scans has become established as a non-invasive and accurate means of diagnosing a variety of inflammatory conditions. We report a retrospective study on leucocyte imaging in the management of 50 patients with systemic vasculitis. Leucocyte imaging was useful for detecting unsuspected sites of disease and monitoring disease activity. Scintigraphy was superior to conventional radiography or CT scanning for detecting and monitoring vasculitic involvement of the respiratory tract. The scans were useful for differentiating between Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA). There was a close and statistically significant relationship between the clinical diagnosis of WG and nasal uptake on leucocyte scans (p
ISSN:0033-5614
1460-2725
1460-2393
1464-3855
1460-2393
DOI:10.1093/oxfordjournals.qjmed.a069094