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Pertussis toxin attenuates atrial natriuretic factor-mediated inhibition of adenylate cyclase. Involvement of inhibitory guanine nucleotide regulatory protein
The effect of pertussis toxin treatment was studied on the inhibitory effect of atrial natriuretic factor (ANF) on adenylate cyclase activity in rat aorta. The incubation of rat aorta washed particles with pertussis toxin and [alpha-32P]NAD resulted in the ADP-ribosylation of a single 40-kDa protein...
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| Published in: | The Journal of biological chemistry 1987-04, Vol.262 (11), p.4931-4934 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c495t-79a1cf1d94b72baea3563baed092506a998f4bc3e712cc62302d896c873e0a583 |
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| cites | cdi_FETCH-LOGICAL-c495t-79a1cf1d94b72baea3563baed092506a998f4bc3e712cc62302d896c873e0a583 |
| container_end_page | 4934 |
| container_issue | 11 |
| container_start_page | 4931 |
| container_title | The Journal of biological chemistry |
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| creator | Anand-Srivastava, M.B. Srivastava, A.K. Cantin, M. |
| description | The effect of pertussis toxin treatment was studied on the inhibitory effect of atrial natriuretic factor (ANF) on adenylate cyclase activity in rat aorta. The incubation of rat aorta washed particles with pertussis toxin and [alpha-32P]NAD resulted in the ADP-ribosylation of a single 40-kDa protein. In addition, pertussis toxin treatment enhanced guanosine 5'-O-(thiotriphosphate) and isoproterenol-stimulated adenylate cyclase activities and attenuated the ANF-mediated inhibition of basal, isoproterenol-, and forskolin-stimulated adenylate cyclase activities. These data suggest that ANF receptors are coupled to adenylate cyclase through inhibitory guanine nucleotide regulatory protein. |
| doi_str_mv | 10.1016/S0021-9258(18)61132-9 |
| format | article |
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These data suggest that ANF receptors are coupled to adenylate cyclase through inhibitory guanine nucleotide regulatory protein.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1016/S0021-9258(18)61132-9</identifier><identifier>PMID: 3031034</identifier><identifier>CODEN: JBCHA3</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>adenylate cyclase ; Adenylate Cyclase Toxin ; Adenylyl Cyclase Inhibitors ; Animals ; aorta ; Aorta - drug effects ; Aorta - enzymology ; atrial natriuretic factor ; Atrial Natriuretic Factor - pharmacology ; Biological and medical sciences ; Bordetella pertussis ; Cell physiology ; Colforsin - pharmacology ; Fundamental and applied biological sciences. Psychology ; GTP-Binding Proteins - metabolism ; Guanosine 5'-O-(3-Thiotriphosphate) ; Guanosine Triphosphate - analogs & derivatives ; Guanosine Triphosphate - pharmacology ; Hormonal regulation ; Isoproterenol - pharmacology ; Male ; Molecular and cellular biology ; Molecular Weight ; NAD - metabolism ; Pertussis Toxin ; Rats ; Rats, Inbred Strains ; Receptors, Atrial Natriuretic Factor ; Receptors, Cell Surface - metabolism ; Thionucleotides - pharmacology ; toxins ; Virulence Factors, Bordetella - pharmacology</subject><ispartof>The Journal of biological chemistry, 1987-04, Vol.262 (11), p.4931-4934</ispartof><rights>1987 © 1987 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-79a1cf1d94b72baea3563baed092506a998f4bc3e712cc62302d896c873e0a583</citedby><cites>FETCH-LOGICAL-c495t-79a1cf1d94b72baea3563baed092506a998f4bc3e712cc62302d896c873e0a583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021925818611329$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7409206$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3031034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anand-Srivastava, M.B.</creatorcontrib><creatorcontrib>Srivastava, A.K.</creatorcontrib><creatorcontrib>Cantin, M.</creatorcontrib><title>Pertussis toxin attenuates atrial natriuretic factor-mediated inhibition of adenylate cyclase. Involvement of inhibitory guanine nucleotide regulatory protein</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>The effect of pertussis toxin treatment was studied on the inhibitory effect of atrial natriuretic factor (ANF) on adenylate cyclase activity in rat aorta. The incubation of rat aorta washed particles with pertussis toxin and [alpha-32P]NAD resulted in the ADP-ribosylation of a single 40-kDa protein. In addition, pertussis toxin treatment enhanced guanosine 5'-O-(thiotriphosphate) and isoproterenol-stimulated adenylate cyclase activities and attenuated the ANF-mediated inhibition of basal, isoproterenol-, and forskolin-stimulated adenylate cyclase activities. These data suggest that ANF receptors are coupled to adenylate cyclase through inhibitory guanine nucleotide regulatory protein.</description><subject>adenylate cyclase</subject><subject>Adenylate Cyclase Toxin</subject><subject>Adenylyl Cyclase Inhibitors</subject><subject>Animals</subject><subject>aorta</subject><subject>Aorta - drug effects</subject><subject>Aorta - enzymology</subject><subject>atrial natriuretic factor</subject><subject>Atrial Natriuretic Factor - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bordetella pertussis</subject><subject>Cell physiology</subject><subject>Colforsin - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>Guanosine 5'-O-(3-Thiotriphosphate)</subject><subject>Guanosine Triphosphate - analogs & derivatives</subject><subject>Guanosine Triphosphate - pharmacology</subject><subject>Hormonal regulation</subject><subject>Isoproterenol - pharmacology</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Molecular Weight</subject><subject>NAD - metabolism</subject><subject>Pertussis Toxin</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Atrial Natriuretic Factor</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Thionucleotides - pharmacology</subject><subject>toxins</subject><subject>Virulence Factors, Bordetella - pharmacology</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><recordid>eNqFkcuKFDEUhgtRxnb0EQYCiuiixpwkdclqkMHLwICCCu5CKnWqO1KVjEmqtV_GZzU1XfR2sjmB_zvXvygugF4ChfrdN0oZlJJV7Rto39YAnJXyUbEB2vKSV_DzcbE5IU-LZzH-ovkJCWfFGaccKBeb4t9XDGmO0UaS_F_riE4J3awTxvwNVo_ELXEOmKwhgzbJh3LC3makJ9btbGeT9Y74gege3WHMAjEHM-qIl-TG7f24xwldWoiV9-FAtrN21iFxsxnRJ9sjCbidc_qi3gWf0LrnxZNBjxFfrPG8-PHxw_frz-Xtl0831-9vSyNklcpGajAD9FJ0Des0al7VPMee5uVpraVsB9EZjg0wY2rGKetbWZu24Uh11fLz4vWxbu77e8aY1GSjwXHUDv0cVdMIwWqoHwRBNKKVgmWwOoIm-BgDDuou2EmHgwKqFgPVvYFqcUdBq-4NVDLnXawN5i6f-ZS1Opb1V6uuo9HjELQzNp6wRuSV6TLnyyO2s9vdHxtQddabHU6K1UwBKCE5ZOrqSGG-7d5iUNFYdCbbG9Ak1Xv7wLj_AeXxx7s</recordid><startdate>19870415</startdate><enddate>19870415</enddate><creator>Anand-Srivastava, M.B.</creator><creator>Srivastava, A.K.</creator><creator>Cantin, M.</creator><general>Elsevier Inc</general><general>American Society for Biochemistry and Molecular Biology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19870415</creationdate><title>Pertussis toxin attenuates atrial natriuretic factor-mediated inhibition of adenylate cyclase. 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Involvement of inhibitory guanine nucleotide regulatory protein</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1987-04-15</date><risdate>1987</risdate><volume>262</volume><issue>11</issue><spage>4931</spage><epage>4934</epage><pages>4931-4934</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><coden>JBCHA3</coden><abstract>The effect of pertussis toxin treatment was studied on the inhibitory effect of atrial natriuretic factor (ANF) on adenylate cyclase activity in rat aorta. The incubation of rat aorta washed particles with pertussis toxin and [alpha-32P]NAD resulted in the ADP-ribosylation of a single 40-kDa protein. In addition, pertussis toxin treatment enhanced guanosine 5'-O-(thiotriphosphate) and isoproterenol-stimulated adenylate cyclase activities and attenuated the ANF-mediated inhibition of basal, isoproterenol-, and forskolin-stimulated adenylate cyclase activities. 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| ispartof | The Journal of biological chemistry, 1987-04, Vol.262 (11), p.4931-4934 |
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| subjects | adenylate cyclase Adenylate Cyclase Toxin Adenylyl Cyclase Inhibitors Animals aorta Aorta - drug effects Aorta - enzymology atrial natriuretic factor Atrial Natriuretic Factor - pharmacology Biological and medical sciences Bordetella pertussis Cell physiology Colforsin - pharmacology Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - metabolism Guanosine 5'-O-(3-Thiotriphosphate) Guanosine Triphosphate - analogs & derivatives Guanosine Triphosphate - pharmacology Hormonal regulation Isoproterenol - pharmacology Male Molecular and cellular biology Molecular Weight NAD - metabolism Pertussis Toxin Rats Rats, Inbred Strains Receptors, Atrial Natriuretic Factor Receptors, Cell Surface - metabolism Thionucleotides - pharmacology toxins Virulence Factors, Bordetella - pharmacology |
| title | Pertussis toxin attenuates atrial natriuretic factor-mediated inhibition of adenylate cyclase. Involvement of inhibitory guanine nucleotide regulatory protein |
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