Clinicopathologic Correlation of Surgically Removed Macular Hole Opercula

To determine the ultrastructural characteristics of the operculum associated with macular holes. We developed instrumentation and a technique to capture the operculum observed with macular holes. Two opercula were studied by transmission electron microscopy. The two specimens were attached to a laye...

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Bibliographic Details
Published in:American journal of ophthalmology 1995-08, Vol.120 (2), p.197-207
Main Authors: MADREPERLA, STEVEN A., MCCUEN, BROOKS W., HICKINGBOTHAM, DYSON, GREEN, W.R.
Format: Article
Language:English
Subjects:
Aged
Astrocytes - ultrastructure
Biological and medical sciences
Collagen - ultrastructure
Female
Fundus Oculi
Humans
Medical sciences
Ophthalmology
Retina - ultrastructure
Retinal Perforations - pathology
Retinal Perforations - surgery
Retinopathies
Visual Acuity
Vitrectomy
Vitreous Body - ultrastructure
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Summary:To determine the ultrastructural characteristics of the operculum associated with macular holes. We developed instrumentation and a technique to capture the operculum observed with macular holes. Two opercula were studied by transmission electron microscopy. The two specimens were attached to a layer of native collagen identified as cortical vitreous and were composed primarily of Mueller cells and fibrous astrocytes without adjacent inner limiting membrane. No distinct retinal neuronal tissue was present. Our findings indicate that proliferation of fibrous astrocytes and Mueller cells occurs with the formation of a macular hole, that this reparative tissue may be dislodged, and it is the reparative tissue that previously has been interpreted as an operculum.
ISSN:0002-9394
1879-1891
DOI:10.1016/S0002-9394(14)72608-X