Local and Systemic Antibody Responses to Shigella Infection in Rhesus Monkeys

Shigella infections are initiated at the surface of the colonic mucosa, and dissemination beyond the intestinal tract is rare. Therefore, the colonic antibody response to Shigella infection is of particular interest. In the current study, this mucosal antibody response has been characterized in a gr...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 1987-05, Vol.155 (5), p.1065-1069
Main Authors: Dinari, Gabriel, Hale, Thomas L., Austin, Smiley W., Formal, Samuel B.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies, Bacterial - biosynthesis
Antibody formation
Antigens
Antigens, Bacterial - genetics
Antigens, Bacterial - immunology
Bacterial diseases
Bacterial Outer Membrane Proteins - immunology
Bacterial Proteins - genetics
Bacterial Proteins - immunology
Biological and medical sciences
Biopsies
Colon - immunology
Concise Communications
Dysentery, Bacillary - immunology
Enzyme linked immunosorbent assay
Experimental bacterial diseases and models
Immunoglobulin A - biosynthesis
Immunoglobulin G - biosynthesis
Infections
Infectious diseases
Intestinal Mucosa - immunology
Macaca mulatta
Medical sciences
Monkeys
Mucosa
Plasmids
Shigella
Shigella flexneri
Shigella flexneri - genetics
Shigella flexneri - immunology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Shigella infections are initiated at the surface of the colonic mucosa, and dissemination beyond the intestinal tract is rare. Therefore, the colonic antibody response to Shigella infection is of particular interest. In the current study, this mucosal antibody response has been characterized in a group of rhesus monkeys challenged with Shigella flexneri serotype 2a. The current study indicates that, in addition to a serum IgG response, a major IgG and IgA response in the colonic mucosa is elicited by these plasmid-coded polypeptides.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/155.5.1065