BIOLOGICAL EFFECTS OF ACETOMYCIN: I. ACTIVITY AGAINST TUMOR CELLS IN VITRO AND IN VIVO

The antibiotic acetomycin was active in vitro against HCT-8 human colon adenocarcinoma cells (IC50, 1.5μg/ml) and L1210 murine leukemia cells (IC50, 2.2μg/ml). Acetomycin also had marked activity in the human tumor stem cell assay, with a 33% overall response rate (

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Bibliographic Details
Published in:Journal of antibiotics 1987/01/25, Vol.40(1), pp.73-76
Main Authors: MAMBER, S. W., MITULSKI, J. D., HAMELEHLE, K. L., FRENCH, J. C., HOKANSON, G. C., SHILLIS, J. L., LEOPOLD, W. R., HOFF, D. D. VON, TUNAC, J. B.
Format: Article
Language:English
Subjects:
Adenocarcinoma
Animals
Antibiotics, Antineoplastic - therapeutic use
Antineoplastic agents
Biological and medical sciences
Cell Line
Cell Survival - drug effects
Chemotherapy
Colonic Neoplasms
Furans - pharmacology
Furans - therapeutic use
Humans
Leukemia L1210 - drug therapy
Medical sciences
Mice
Pharmacology. Drug treatments
Tumor Stem Cell Assay
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Description
Summary:The antibiotic acetomycin was active in vitro against HCT-8 human colon adenocarcinoma cells (IC50, 1.5μg/ml) and L1210 murine leukemia cells (IC50, 2.2μg/ml). Acetomycin also had marked activity in the human tumor stem cell assay, with a 33% overall response rate (
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.40.73