Scedosporium prolificans, a multi-resistant fungus, from a U.K. AIDS patient

We report the first isolation of Scedosporium prolificans (inflatum) in the U.K. The patient, with advanced AIDS and neutropenia, had respiratory tract colonisation over many months without invasive disease despite neutropenia, while on itraconazole therapy. The organism was resistant in vitro to al...

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Bibliographic Details
Published in:The Journal of infection 1995, Vol.30 (2), p.153-155
Main Authors: Hopwood, V., Evans, E.G.V., Matthews, J., Denning, D.W.
Format: Article
Language:English
Subjects:
Adult
AIDS-Related Opportunistic Infections - microbiology
AIDS/HIV
Antifungal Agents - pharmacology
Biological and medical sciences
Culture Media
Drug Resistance, Multiple
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Male
Medical sciences
Microbial Sensitivity Tests
Mitosporic Fungi - drug effects
Mitosporic Fungi - growth & development
Mitosporic Fungi - isolation & purification
Mycoses - microbiology
Risk Factors
Scedosporium prolificans
United Kingdom
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Summary:We report the first isolation of Scedosporium prolificans (inflatum) in the U.K. The patient, with advanced AIDS and neutropenia, had respiratory tract colonisation over many months without invasive disease despite neutropenia, while on itraconazole therapy. The organism was resistant in vitro to all licensed systemic antifungal agents tested.
ISSN:0163-4453
1532-2742
DOI:10.1016/S0163-4453(95)80011-5