How safe are the xenogeneic hemostats? - Report of a case of severe systemic allergic reaction

We report herein the unusual case of a 55-year-old woman who developed a severe systemic allergy to Avitene (microfibrillar collagen hydrochloride), a xenogeneic agent sometimes used for topical hemostasis in laparoscopic cholecystectomy. The patient developed fever, general fatigue, mild liver dysf...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 1995-01, Vol.25 (5), p.433-435
Main Authors: KITAMURA, K, YASUOKA, R, OHARA, M, SHIMOTSUMA, M, HAGIWARA, A, YAMANE, T, YAMAGUCHI, T, TAKAHASHI, T
Format: Article
Language:English
Subjects:
Abdominal Abscess - diagnosis
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Cholecystectomy, Laparoscopic
Collagen - adverse effects
Diagnosis, Differential
Drug Hypersensitivity - diagnosis
Female
Hemostasis, Surgical
Hemostatics - adverse effects
Humans
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Postoperative Complications - diagnosis
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Summary:We report herein the unusual case of a 55-year-old woman who developed a severe systemic allergy to Avitene (microfibrillar collagen hydrochloride), a xenogeneic agent sometimes used for topical hemostasis in laparoscopic cholecystectomy. The patient developed fever, general fatigue, mild liver dysfunction, and prominent eosinophilia postoperatively. A skin allergy test confirmed that these abnormal findings were attributable to an allergic reaction to Avitene.
ISSN:0941-1291
1436-2813
DOI:10.1007/BF00311821