Effects of Submaxillariectomy on Ovarian Androgen and Estrogen Production in Adult Female Rats

Submaxillariectomy causes an increase in uterine weight in adult female rats. This increase is due to the elevation of the plasma 17β-estradiol (E2) level which is brought on by enhancement of ovarian E2 production. Furthermore, enhancement of ovarian E2 production is due to the enhancement of testo...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1995-08, Vol.213 (2), p.550-554
Main Authors: Tanaka, M., Watanabe, M., Kumai, T., Nakura, H., Kobayashi, S.
Format: Article
Language:English
Subjects:
17-alpha-Hydroxyprogesterone
Androgens - biosynthesis
Androstenedione - biosynthesis
Animals
Estradiol - biosynthesis
Female
Hydroxyprogesterones - metabolism
Organ Size
Ovary - metabolism
Progesterone - biosynthesis
Rats
Rats, Sprague-Dawley
Submandibular Gland - physiology
Submandibular Gland - surgery
Testosterone - biosynthesis
Uterus - anatomy & histology
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Summary:Submaxillariectomy causes an increase in uterine weight in adult female rats. This increase is due to the elevation of the plasma 17β-estradiol (E2) level which is brought on by enhancement of ovarian E2 production. Furthermore, enhancement of ovarian E2 production is due to the enhancement of testosterone and androstenedione production which are the precursors of ovarian E2. However, submaxillariectomy did not affect ovarian progesterone and 17α-hydroxyprogesterone levels. These findings suggest that the submaxillary gland may inhibit the production of ovarian E2 mainly because of the inhibition of ovarian androgen production. Thus the submaxillary gland may play a physiological role in female reproductive systems caused by the change in ovarian steroidogenesis.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1995.2166