Knowledge-based prediction of protein structures and the design of novel molecules

Prediction of the tertiary structures of proteins may be carried out using a knowledge-based approach. This depends on identification of analogies in secondary structures, motifs, domains or ligand interactions between a protein to be modelled and those of known three-dimensional structures. Such te...

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Bibliographic Details
Published in:Nature (London) 1987-03, Vol.326 (6111), p.347-352
Main Authors: Blundell, T. L, Sibanda, B. L, Sternberg, M. J. E, Thornton, J. M
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Animals
Base Sequence
Biological and medical sciences
Design
DNA, Recombinant
Forecasting
Fundamental and applied biological sciences. Psychology
General aspects, investigation methods
Humans
Macromolecular Substances
Models, Molecular
Molecules
Pesticides
Protein Conformation
Proteins
Proteins - genetics
reviews
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Summary:Prediction of the tertiary structures of proteins may be carried out using a knowledge-based approach. This depends on identification of analogies in secondary structures, motifs, domains or ligand interactions between a protein to be modelled and those of known three-dimensional structures. Such techniques are of value in prediction of receptor structures to aid the design of drugs, herbicides or pesticides, antigens in vaccine design, and novel molecules in protein engineering.
ISSN:0028-0836
1476-4687
DOI:10.1038/326347a0