Amniotic fluid interleukin-6: Correlation with upper genital tract microbial colonization and gestational age in women delivered after spontaneous labor versus indicated delivery

OBJECTIVE: Our purpose was to determine whether amniotic fluid interleukin-6 is increased and inversely proportional to gestational age in women with chorioamnion colonization and spontaneous labor versus women delivered for medical or obstetric indications. STUDY DESIGN: The chorioamnion and amniot...

Full description

Saved in:
Bibliographic Details
Published in:American journal of obstetrics and gynecology 1995-08, Vol.173 (2), p.606-612
Main Authors: Andrews, William W., Hauth, John C., Goldenberg, Robert L., Gomez, Ricardo, Romero, Roberto, Cassell, Gail H.
Format: Article
Language:English
Subjects:
Amnion - chemistry
Amnion - microbiology
Amnion - parasitology
Amniotic Fluid - chemistry
Amniotic Fluid - microbiology
Amniotic Fluid - parasitology
Animals
Biological and medical sciences
Cesarean Section
Chlamydia trachomatis - isolation & purification
Chorioamnion infection
chorioamnionitis
Chorion - chemistry
Chorion - microbiology
Chorion - parasitology
Culture Techniques
Female
Genital system. Mammary gland
Gestational Age
Humans
interleukin-6
Interleukin-6 - analysis
Investigative techniques, diagnostic techniques (general aspects)
Labor, Induced
Labor, Obstetric
Medical sciences
Mycoplasma - isolation & purification
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Pregnancy
prematurity
preterm labor
Trial of Labor
Trichomonas vaginalis - isolation & purification
Ureaplasma urealyticum - isolation & purification
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:OBJECTIVE: Our purpose was to determine whether amniotic fluid interleukin-6 is increased and inversely proportional to gestational age in women with chorioamnion colonization and spontaneous labor versus women delivered for medical or obstetric indications. STUDY DESIGN: The chorioamnion and amniotic fluid were cultured at cesarean delivery for aerobic and anaerobic bacteria, fungi, mycoplasmas, Chlamydia trachomatis and Trichomonas vaginalis in 269 women with singleton gestations with intact membranes. The amniotic fluid interleukin-6 concentration was also determined. RESULTS: Amniotic fluid interleukin-6 levels were (1) higher in women with spontaneous labor versus those with indicated deliveries (15.8 ± 5.0 vs 2.2 ± 0.2 ng/ml, p = 0.01), (2) inversely proportional to gestational age in women with spontaneous labor (
ISSN:0002-9378
1097-6868
DOI:10.1016/0002-9378(95)90290-2