In vitro activity of RP 59500 (quinupristin/dalfopristin) against antibiotic-resistant strains of Streptococcus pneumoniae and Enterococci

The activity of RP 59500 (quinupristin/dalfopristin) was evaluated in vitro against antibiotic-resistant strains of Streptococcus pneumoniae (N = 15) and Enterococcus spp. (N = 43). By broth dilution MIC tests RP 59500 was highly active against penicillin-resistant S. pneumoniae and vancomycin-resis...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 1995-03, Vol.21 (3), p.169-173
Main Authors: Johnson, Caroline C., Slavoski, Linda, Schwartz, Mary, May, Phyllis, Pitsakis, Peter G., Shur, Andrew L., Levison, Matthew E.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Drug Resistance, Microbial
Enterococcus - drug effects
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Streptococcus pneumoniae - drug effects
Virginiamycin - pharmacology
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Summary:The activity of RP 59500 (quinupristin/dalfopristin) was evaluated in vitro against antibiotic-resistant strains of Streptococcus pneumoniae (N = 15) and Enterococcus spp. (N = 43). By broth dilution MIC tests RP 59500 was highly active against penicillin-resistant S. pneumoniae and vancomycin-resistant Enterococcus faecium, but showed poor activity against E. faecalis. In time-kill studies the drug was rapidly bactericidal against S. pneumoniae but failed to kill most enterococci, even in the presence of gentamicin or human serum.
ISSN:0732-8893
1879-0070
DOI:10.1016/0732-8893(95)00068-L