Liver transplantation and haemophilia A

Liver transplantation has become the standard treatment for a variety of inherited metabolic disorders. We report on two patients who underwent successful transplantation for posthepatitis viral cirrhosis, which developed following blood factor replacement for haemophilia A. The second patient was t...

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Bibliographic Details
Published in:Journal of hepatology 1995-05, Vol.22 (5), p.583-585
Main Authors: Lerut, Jan P., Laterre, Pierre-François, Lavenne-Pardonge, Edith, Donataccio, Matteo, Geubel, André, Reynaert, Marc S., Otte, Jean-Bernard
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Coagulation Factors - adverse effects
Hematologic and hematopoietic diseases
Hemophilia A
Hemophilia A - complications
Hemophilia A - therapy
Hemophilia B
Hepatitis, Viral, Human - etiology
Humans
Inherited metabolic disease
Liver Cirrhosis - virology
Liver Transplantation
Male
Medical sciences
Metabolic cure
Middle Aged
Platelet diseases and coagulopathies
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Summary:Liver transplantation has become the standard treatment for a variety of inherited metabolic disorders. We report on two patients who underwent successful transplantation for posthepatitis viral cirrhosis, which developed following blood factor replacement for haemophilia A. The second patient was transplanted before the occurrence of major complications of either his liver or haemophilic disease. We propose early liver transplantation to achieve metabolic cure of haemophilia.
ISSN:0168-8278
1600-0641
DOI:10.1016/0168-8278(95)80454-4