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Comparison of effects of N-3 to N-6 fatty acids on serum level of lipoprotein(a) in patients with coronary artery disease

The influence of dietary supplementation with n-3 versus n-6 fatty acids on plasma lipoprotein(a) (Lp[a]) levels was studied. Thirty-five male hospitalized patients with coronary artery disease were treated for 4 weeks with 12 g/day of fish oil (≈8.5 g of n-3 fatty acids) in combination with a 5, 00...

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Published in:The American journal of cardiology 1995-09, Vol.76 (7), p.459-462
Main Authors: Herrmann, Wolfgang, Biermann, Ju¨rgen, Kostner, Gert M.
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description The influence of dietary supplementation with n-3 versus n-6 fatty acids on plasma lipoprotein(a) (Lp[a]) levels was studied. Thirty-five male hospitalized patients with coronary artery disease were treated for 4 weeks with 12 g/day of fish oil (≈8.5 g of n-3 fatty acids) in combination with a 5, 000 kilojoule, 30% fat diet and moderate exercise. Eighteen control patients given the same dietary and training program were treated with 12 g/day of rapeseed oil. Plasma Lp(a), in addition to several lipids and lipoproteins, blood clotting factors, and platelet reactivity, were measured before and at the end of therapy. Results can be summarized as follows: total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B levels decreased significantly in both the rapeseed oil (−14.4%, −20.3%, −15.2%, respectively) and fish oil (−12.2%, −16.0%, and −14.2%, respectively) groups. Triglycerides decreased (−20.3%) and high-density lipoprotein cholesterol increased (+8.3%) significantly only in patients treated with fish oil. Plasma Lp(a) levels were reduced by 14% in the fish oil group, but unaffected in the rapeseed oil group. Patients treated with fish oil could be categorized into 2 subgroups: “responders”, with a reduction in Lp(a) by 24% and “nonresponders”, with a small nonsignificant increase in serum Lp(a). Responders and nonresponders exhibited a marked reduction in cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and triglycerides, and an increase in high-density lipoprotein 3 cholesterol. There was a large reduction in tissue plasminogen activator in the fish oil group, which correlated significantly with reduction in Lp(a). Platelet number and aggregation behavior were not significantly changed in either group. No physiologic differences were seen between responders and nonresponders.
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Thirty-five male hospitalized patients with coronary artery disease were treated for 4 weeks with 12 g/day of fish oil (≈8.5 g of n-3 fatty acids) in combination with a 5, 000 kilojoule, 30% fat diet and moderate exercise. Eighteen control patients given the same dietary and training program were treated with 12 g/day of rapeseed oil. Plasma Lp(a), in addition to several lipids and lipoproteins, blood clotting factors, and platelet reactivity, were measured before and at the end of therapy. Results can be summarized as follows: total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B levels decreased significantly in both the rapeseed oil (−14.4%, −20.3%, −15.2%, respectively) and fish oil (−12.2%, −16.0%, and −14.2%, respectively) groups. Triglycerides decreased (−20.3%) and high-density lipoprotein cholesterol increased (+8.3%) significantly only in patients treated with fish oil. Plasma Lp(a) levels were reduced by 14% in the fish oil group, but unaffected in the rapeseed oil group. Patients treated with fish oil could be categorized into 2 subgroups: “responders”, with a reduction in Lp(a) by 24% and “nonresponders”, with a small nonsignificant increase in serum Lp(a). Responders and nonresponders exhibited a marked reduction in cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and triglycerides, and an increase in high-density lipoprotein 3 cholesterol. There was a large reduction in tissue plasminogen activator in the fish oil group, which correlated significantly with reduction in Lp(a). Platelet number and aggregation behavior were not significantly changed in either group. 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Thirty-five male hospitalized patients with coronary artery disease were treated for 4 weeks with 12 g/day of fish oil (≈8.5 g of n-3 fatty acids) in combination with a 5, 000 kilojoule, 30% fat diet and moderate exercise. Eighteen control patients given the same dietary and training program were treated with 12 g/day of rapeseed oil. Plasma Lp(a), in addition to several lipids and lipoproteins, blood clotting factors, and platelet reactivity, were measured before and at the end of therapy. Results can be summarized as follows: total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B levels decreased significantly in both the rapeseed oil (−14.4%, −20.3%, −15.2%, respectively) and fish oil (−12.2%, −16.0%, and −14.2%, respectively) groups. Triglycerides decreased (−20.3%) and high-density lipoprotein cholesterol increased (+8.3%) significantly only in patients treated with fish oil. Plasma Lp(a) levels were reduced by 14% in the fish oil group, but unaffected in the rapeseed oil group. Patients treated with fish oil could be categorized into 2 subgroups: “responders”, with a reduction in Lp(a) by 24% and “nonresponders”, with a small nonsignificant increase in serum Lp(a). Responders and nonresponders exhibited a marked reduction in cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and triglycerides, and an increase in high-density lipoprotein 3 cholesterol. There was a large reduction in tissue plasminogen activator in the fish oil group, which correlated significantly with reduction in Lp(a). Platelet number and aggregation behavior were not significantly changed in either group. No physiologic differences were seen between responders and nonresponders.</description><subject>Apolipoproteins B - blood</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Cholesterol - blood</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - diet therapy</subject><subject>Coronary Disease - drug therapy</subject><subject>Coronary heart disease</subject><subject>Diet</subject><subject>Diet, Fat-Restricted</subject><subject>Diet, Reducing</subject><subject>Double-Blind Method</subject><subject>Exercise</subject><subject>Fatty Acids, Monounsaturated</subject><subject>Fatty Acids, Omega-3 - therapeutic use</subject><subject>Fatty Acids, Omega-6</subject><subject>Fatty Acids, Unsaturated - therapeutic use</subject><subject>Heart</subject><subject>Humans</subject><subject>Lipoprotein(a) - blood</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Plant Oils - therapeutic use</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Count - drug effects</subject><subject>Proteins</subject><subject>Rapeseed Oil</subject><subject>Tissue Plasminogen Activator - blood</subject><subject>Triglycerides - blood</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNqFkUtv1DAUhS0EKkPhJ1SyEELtImDHj9irCo14SRUsgLVl7BvhKrGD7RT13-N0RrNgw-rGup-PT85B6IKSN5RQ-fYbIaTvNOX6UusrRSgjHX2EdlQNuqOassdod0Keomel3LYjpUKeobNBCsY536H7fZoXm0NJEacRwziCq2X7_NIxXFMbEo-21ntsXfBtE3GBvM54gjuYNnAKS1pyqhDipb3CIeLF1gCxyfwJ9Rd2KadocxPIFdrwoYAt8Bw9Ge1U4MVxnqMfH95_33_qbr5-_Lx_d9M5TmXteA9OyUFZxj1hg3WDcpT0MAipQHjKekH86IkEpZnzmoLomeVWKfCjbTGco9cH3ebx9wqlmjkUB9NkI6S1mGHgUvRcNPDlP-BtWnNs3kzP2tOE0w0SB8jlVEqG0Sw5zO3vDCVm68U89GK20I3W5qEXs7m4OIqvP2fwp1vHItr-1XFvi7PTmG10oZwwJrlQfGjY9QGDlthdgGyKa1E78CG34oxP4T9G_gJp36il</recordid><startdate>19950901</startdate><enddate>19950901</enddate><creator>Herrmann, Wolfgang</creator><creator>Biermann, Ju¨rgen</creator><creator>Kostner, Gert M.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19950901</creationdate><title>Comparison of effects of N-3 to N-6 fatty acids on serum level of lipoprotein(a) in patients with coronary artery disease</title><author>Herrmann, Wolfgang ; Biermann, Ju¨rgen ; Kostner, Gert M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-42ec8678a34d037ac78c102e7568e5d13250dfd06e893cd91e523a4a88edfa913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Apolipoproteins B - blood</topic><topic>Biological and medical sciences</topic><topic>Cardiology. 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Thirty-five male hospitalized patients with coronary artery disease were treated for 4 weeks with 12 g/day of fish oil (≈8.5 g of n-3 fatty acids) in combination with a 5, 000 kilojoule, 30% fat diet and moderate exercise. Eighteen control patients given the same dietary and training program were treated with 12 g/day of rapeseed oil. Plasma Lp(a), in addition to several lipids and lipoproteins, blood clotting factors, and platelet reactivity, were measured before and at the end of therapy. Results can be summarized as follows: total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B levels decreased significantly in both the rapeseed oil (−14.4%, −20.3%, −15.2%, respectively) and fish oil (−12.2%, −16.0%, and −14.2%, respectively) groups. Triglycerides decreased (−20.3%) and high-density lipoprotein cholesterol increased (+8.3%) significantly only in patients treated with fish oil. Plasma Lp(a) levels were reduced by 14% in the fish oil group, but unaffected in the rapeseed oil group. Patients treated with fish oil could be categorized into 2 subgroups: “responders”, with a reduction in Lp(a) by 24% and “nonresponders”, with a small nonsignificant increase in serum Lp(a). Responders and nonresponders exhibited a marked reduction in cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and triglycerides, and an increase in high-density lipoprotein 3 cholesterol. There was a large reduction in tissue plasminogen activator in the fish oil group, which correlated significantly with reduction in Lp(a). Platelet number and aggregation behavior were not significantly changed in either group. No physiologic differences were seen between responders and nonresponders.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7653444</pmid><doi>10.1016/S0002-9149(99)80130-1</doi><tpages>4</tpages></addata></record>
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subjects Apolipoproteins B - blood
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular disease
Cholesterol - blood
Coronary Disease - blood
Coronary Disease - diet therapy
Coronary Disease - drug therapy
Coronary heart disease
Diet
Diet, Fat-Restricted
Diet, Reducing
Double-Blind Method
Exercise
Fatty Acids, Monounsaturated
Fatty Acids, Omega-3 - therapeutic use
Fatty Acids, Omega-6
Fatty Acids, Unsaturated - therapeutic use
Heart
Humans
Lipoprotein(a) - blood
Male
Medical research
Medical sciences
Middle Aged
Plant Oils - therapeutic use
Platelet Aggregation - drug effects
Platelet Count - drug effects
Proteins
Rapeseed Oil
Tissue Plasminogen Activator - blood
Triglycerides - blood
title Comparison of effects of N-3 to N-6 fatty acids on serum level of lipoprotein(a) in patients with coronary artery disease
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