Abnormal monitoring of inner speech: a physiological basis for auditory hallucinations

Auditory verbal hallucinations ("voices") are thought to arise from a disorder of inner speech (thinking in words). We examined the neural correlates of tasks which involve inner speech in subjects with schizophrenia who hear voices (hallucinators), subjects with schizophrenia who do not (...

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Bibliographic Details
Published in:The Lancet (British edition) 1995-09, Vol.346 (8975), p.596-600
Main Authors: McGuire, P.K., David, A.S., Murray, R.M., Frackowiak, R.S.J., Frith, C.D., Wright, I., Silbersweig, D.A.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Auditory hallucinations
Auditory Perceptual Disorders - complications
Auditory Perceptual Disorders - diagnosis
Biological and medical sciences
Brain
Cerebrovascular Circulation
Cognition & reasoning
Hallucinations - etiology
Hallucinations - physiopathology
Humans
Inner speech
Male
Medical research
Medical sciences
Mental disorders
Patients
Physiological aspects
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - complications
Speech Perception - physiology
Tomography, Emission-Computed
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Summary:Auditory verbal hallucinations ("voices") are thought to arise from a disorder of inner speech (thinking in words). We examined the neural correlates of tasks which involve inner speech in subjects with schizophrenia who hear voices (hallucinators), subjects with schizophrenia who do not (nonhallucinators), and normal controls. There were no differences between hallucinators and controls in regional cerebral blood flow during thinking in sentences. However, when imagining sentences being spoken in another person's voice—which entails both the generation and monitoring of inner speech—hallucinators had a normal left frontal response, but reduced activation in the left middle temporal gyrus and the rostral supplementary motor area, regions which were activated by both normal subjects and nonhallucinators (p
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(95)91435-8