Bone loss in patients with inflammatory bowel disease: a prospective study

To assess the rate of bone loss in patients with inflammatory bowel disease, we prospectively studied 35 patients (17 women) aged 36 +/- 13 (range 17-60) years, 14 of whom had Crohn's disease and 21 with ulcerative colitis (including 12 with ileoanal anastomosis). Bone mineral density was measu...

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Bibliographic Details
Published in:Osteoporosis international 1995-05, Vol.5 (3), p.156-160
Main Authors: ROUX, C, ABITBOL, V, CHAUSSADE, S, KOLTA, S, GUILLEMANT, S, DOUGADOS, M, AMOR, B, COUTURIER, D
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adult
Biological and medical sciences
Bone Density
Colitis, Ulcerative - complications
Colitis, Ulcerative - surgery
Crohn Disease - complications
Female
Femur Neck - metabolism
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Inflammatory Bowel Diseases - complications
Lumbar Vertebrae - metabolism
Male
Medical sciences
Osteoporosis - etiology
Osteoporosis - metabolism
Other diseases. Semiology
Proctocolectomy, Restorative
Prospective Studies
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:To assess the rate of bone loss in patients with inflammatory bowel disease, we prospectively studied 35 patients (17 women) aged 36 +/- 13 (range 17-60) years, 14 of whom had Crohn's disease and 21 with ulcerative colitis (including 12 with ileoanal anastomosis). Bone mineral density was measured by dual-energy X-ray absorptiometry at the lumbar spine and femoral neck. The follow-up was 19 +/- 8 months. During this period, 14 patients received oral steroids. Lumbar bone density changes expressed as a percentage per year were -3.1 +/- 4.9%, -6.4 +/- 7.5% and +2.0 +/- 4.0% in Crohn's disease and ulcerative colitis without and with ileoanal anastomosis respectively (p = 0.007). The same pattern was observed at the femoral neck. Mean annual lumbar bone density changes were -6.2 +/- 7.0% and +0.9 +/- 3.9% in patients with and without steroids during follow-up (p = 0.002). We conclude that patients with inflammatory bowel disease are at risk of lumbar and femoral bone loss. However, bone loss is not observed in patients with ileoanal anastomosis.
ISSN:0937-941X
1433-2965
DOI:10.1007/BF02106094