Mseleni disease serum is not harmful to cultured chondrocytes

The origins of Mseleni disease, an acquired polyarticular degenerative joint disease, are unknown. We examined sera from 12 patients with the disease, 5 unaffected Mseleni residents, and 5 Durban residents. The effects of sera from the 12 patients with Mseleni disease on DNA or sulfated proteoglycan...

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Bibliographic Details
Published in:Arthritis and rheumatism 1987-03, Vol.30 (3), p.348-352
Main Authors: Changlong, Yu, Fincham, John E., Wright, George C., Taljaard, Joshua J. F., Sokoloff, Leon
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cartilage, Articular - metabolism
Cartilage, Articular - pathology
Cell Count
Cell Division
Cells, Cultured
Diseases of the osteoarticular system
Female
Humans
Male
Medical sciences
Middle Aged
Miscellaneous. Osteoarticular involvement in other diseases
Osteoarthritis
Osteoarthritis - blood
Proteoglycans - biosynthesis
Tropical medicine
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Summary:The origins of Mseleni disease, an acquired polyarticular degenerative joint disease, are unknown. We examined sera from 12 patients with the disease, 5 unaffected Mseleni residents, and 5 Durban residents. The effects of sera from the 12 patients with Mseleni disease on DNA or sulfated proteoglycan synthesis by cultured rabbit or human infant articular chondrocytes were no different from those of control sera. Cells derived from 2 children contained no stainable DR antigens; coculture had no impact on either of the above measures of cell function.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780300316