Effects of Taurine and Hypotaurine on Lipid Peroxidation

It has been suggested that hypotaurine might inhibit lipid peroxidation in vivo by scavenging the initiator OH. The results presented demonstrate that hypotaurine affects other reactions relevant to the initiation, propagation and termination phases of lipid peroxidation. Hypotaurine a) decreases Fe...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1995-08, Vol.213 (3), p.820-826
Main Authors: Tadolini, B., Pintus, G., Pinna, G.G., Bennardini, F., Franconi, F.
Format: Article
Language:English
Subjects:
CATION
CATIONES
Dimyristoylphosphatidylcholine
FER
Ferric Compounds - metabolism
Ferrous Compounds - metabolism
HIERRO
LECITHINE
LECITINAS
Lipid Peroxidation - drug effects
LIPOSOMAS (ORGANULOS)
LIPOSOME (ORGANITE)
Liposomes
OXIDACION
Oxidation-Reduction
OXYDATION
PEROXIDACION LIPIDICA
PEROXYDATION DES LIPIDES
Phosphatidic Acids
TAURINA
TAURINE
Taurine - analogs & derivatives
Taurine - pharmacology
VITELLUS
YEMA DE HUEVO
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Summary:It has been suggested that hypotaurine might inhibit lipid peroxidation in vivo by scavenging the initiator OH. The results presented demonstrate that hypotaurine affects other reactions relevant to the initiation, propagation and termination phases of lipid peroxidation. Hypotaurine a) decreases Fe 2+ autoxidation, either spontaneous or catalyzed by Fe 3+ that may generate perferryl iron; b) decreases Fe 2+ oxidation, by cumene hydroperoxide, that forms the alkoxy radical; c) inhibits the lipid hydroperoxide dependent-lipid peroxidation, favoring the onset of the termination phase. Hypotaurine does not affect the autoxidation of Fe 2+ bound to phosphatidic acid containing liposomes. Taurine is ineffective in all the experimental systems tested.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1995.2203