Effect of L-threo-3, 4-Dihydroxyphenylserine (L-DOPS), an Immediate Precursor of Norepinephrine, on the Cerebral Blood Flow in Rats

L-threo-3, 4-Dihydroxyphenylserine (L-DOPS), a norepinephrine (NE) precursor, 3 mg/kg, i.v., increased the cerebral blood flow (CBF) in both the striatum and hippocampus as well as the mean arterial blood pressure (MABP) in urethane-anesthetized rats, as NE infusion did. The L-DOPS induced increase...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1987, Vol.43(1), pp.91-93
Main Authors: SATO, Etsuro, IRIE, Tsunemasa, KATSUBE, Junki
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Catecholaminergic system
Cerebrovascular Circulation - drug effects
Corpus Striatum - blood supply
Droxidopa - pharmacology
Hippocampus - drug effects
Male
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Norepinephrine - pharmacology
Pharmacology. Drug treatments
Propranolol - pharmacology
Rats
Rats, Inbred Strains
Serine - analogs & derivatives
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Summary:L-threo-3, 4-Dihydroxyphenylserine (L-DOPS), a norepinephrine (NE) precursor, 3 mg/kg, i.v., increased the cerebral blood flow (CBF) in both the striatum and hippocampus as well as the mean arterial blood pressure (MABP) in urethane-anesthetized rats, as NE infusion did. The L-DOPS induced increase in CBF was inhibited by benserazide (3 mg/kg/hour), a peripheral aromatic L-amino acid decarboxylase inhibitor, and propranolol (3 mg/kg, i.p.), a β-adrenoceptor blocker as well. These results suggest that the effects of L-DOPS may be attributed to the action of NE formed from L-DOPS, and the action may be mediated by stimulation of β-adrenoceptor.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.43.91