Cervicovaginal Overproduction of Specific IgG to Human Immunodeficiency Virus (HIV) Contrasts with Normal or Impaired IgA Local Response in HIV Infection

Paired sera and cervicovaginal secretions (CVS) from 30 women infected with human immunodeficiency virus (HIV) type 1 (before AIDS) were analyzed for IgG and IgA antibodies to HIV and for IgG, IgA, and human serum albumin. Subjects were compared with 30 age-matched healthy controls. In HIV-infected...

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Bibliographic Details
Published in:The Journal of infectious diseases 1995-09, Vol.172 (3), p.691-697
Main Authors: Bélec, Laurent, Dupré, Thierry, Prazuck, Thierry, Tévi-Bénissan, Carol, Kanga, Jean-Marie, Pathey, Olivier, Lu, Xhu-Sheng, Pillot, Jacques
Format: Article
Language:English
Subjects:
Adolescent
Adult
Africa - ethnology
AIDS/HIV
Antibodies
Antibody Specificity
Biological and medical sciences
Black people
Cervix Uteri - immunology
Female
France
Health savings accounts
Hemic system
HIV
HIV 1
HIV Antibodies - biosynthesis
HIV Antibodies - blood
HIV Infections - blood
HIV Infections - immunology
human immunodeficiency virus 1
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulin A - biosynthesis
Immunoglobulin A - blood
Immunoglobulin G - biosynthesis
Immunoglobulin G - blood
Immunoglobulins
Immunopathology
Isotypes
Lactoferrin - analysis
Major Articles
Medical sciences
Middle Aged
Mucosa
Reference Values
Secretion
Serum Albumin - analysis
Vagina - immunology
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Summary:Paired sera and cervicovaginal secretions (CVS) from 30 women infected with human immunodeficiency virus (HIV) type 1 (before AIDS) were analyzed for IgG and IgA antibodies to HIV and for IgG, IgA, and human serum albumin. Subjects were compared with 30 age-matched healthy controls. In HIV-infected women, cervicovaginal immunoglobulins were markedly increased, and IgG predominated. An increased immunoglobulin transudation was implicated, since cervicovaginal albumin levels were 2.3-fold above those of normal controls. Furthermore, IgG excretion by reference to albumin was increased 1.9-fold, whereas the IgA secretion tended to decrease, suggesting a possible enhanced local IgG synthesis. Mean IgG and IgA anti-HIV antibody titers were, respectively, 30- and 12-fold higher in serum than in CVS, but their mean specific activities were higher in CVS than in serum, suggesting a local synthesis of both isotypes. The IgA antibody response to HIV remained poor compared with the strong IgG response.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/172.3.691