Serotonergic Stimulation of Prolactin Secretion Is Inhibited by Vasoactive Intestinal Peptide Immunoneutralization in the Turkey

The neuronal mechanisms that govern prolactin (PRL) secretion in the turkey appear to involve monoaminergic systems. Considerable evidence indicates that serotonin (5-HT), acting centrally, is a potent stimulator of PRL secretion. This study, using birds actively immunized against VIP, tests the hyp...

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Bibliographic Details
Published in:General and comparative endocrinology 1995-07, Vol.99 (1), p.69-74
Main Authors: El Halawani, M.E., Youngren, O.M., Rozenboim, J., Pitts, G.R., Silsby, J.L., Phillips, R.E.
Format: Article
Language:English
Subjects:
Animals
Brain - drug effects
DINDON
ESTIMULO
Female
FEMELLE
HEMBRA
HORMONAS
HORMONE
IMMUNISATION
Immunization
INHIBICION
INHIBITION
INMUNIZACION
Kinetics
Methysergide - pharmacology
PAVO
PEPTIDE
PEPTIDOS
PLASMA SANGUIN
PLASMA SANGUINEO
POLLO
POULET
Prolactin - metabolism
PROLACTINA
PROLACTINE
Quipazine - pharmacology
SECRECION
SECRETION
Serotonin - administration & dosage
Serotonin - pharmacology
SEROTONINA
SEROTONINE
STIMULUS
Turkeys
Vasoactive Intestinal Peptide - immunology
Vasoactive Intestinal Peptide - physiology
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Description
Summary:The neuronal mechanisms that govern prolactin (PRL) secretion in the turkey appear to involve monoaminergic systems. Considerable evidence indicates that serotonin (5-HT), acting centrally, is a potent stimulator of PRL secretion. This study, using birds actively immunized against VIP, tests the hypothesis that 5-HT stimulates PRL secretion by releasing vasoactive intestinal peptide (VIP). Nonimmunized turkeys were injected ip with saline, quipazine (5-HT agonist; 5 mg/kg), methysergide (5-HT antagonist; 8 mg/kg), or methysergide plus quipazine, and VIP-immunized birds were injected with saline or quipazine. Quipazine increased plasma PRL levels from 26.8 ± 7.1 ng/ml at Time 0 to a peak value of 148.1 ± 31.4 ng/ml 2 hr after injection. Pretreatment with methysergide or VIP-immunoneutralization abolished the PRL response to quipazine. Intraventricular infusion of 5-HT (1 nmol/min) caused plasma PRL to rise from a baseline of 16.3 ± 2.6 ng/ml to 85.2 ± 14.3 ng/ml after 30 min in nonimmunized control birds. Serotonin infusion did not induce PRL secretion in the VIP immunized birds. These findings suggest that serotonergic stimulation of PRL secretion in the female turkey requires a functional VIPergic system.
ISSN:0016-6480
1095-6840
DOI:10.1006/gcen.1995.1086