Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds

Several polyphenolic compounds were tested for the inhibition of lung metastasis induced by B16F10 melanoma cells in mice. Oral administration of polyphenols such as curcumin and catechin at concentrations of 200 nmol/kg body weight were found to inhibit the lung metastasis maximally as seen by the...

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Bibliographic Details
Published in:Cancer letters 1995-08, Vol.95 (1), p.221-225
Main Authors: Menon, Lata G., Kuttan, Ramadasan, Kuttan, Girija
Format: Article
Language:English
Subjects:
Animals
Anti-metastatic activity
Biological and medical sciences
Catechin - pharmacology
Cell Survival - drug effects
Curcumin - pharmacology
Female
Flavonoids
General pharmacology
Lung Neoplasms - secondary
Medical sciences
Melanoma, Experimental - pathology
Mice
Mice, Inbred C57BL
Neoplasm Metastasis - prevention & control
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenols - pharmacology
Polymers - pharmacology
Polyphenols
Rutin - pharmacology
Survival Analysis
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Summary:Several polyphenolic compounds were tested for the inhibition of lung metastasis induced by B16F10 melanoma cells in mice. Oral administration of polyphenols such as curcumin and catechin at concentrations of 200 nmol/kg body weight were found to inhibit the lung metastasis maximally as seen by the reduction in the number of lung tumor nodules (80%). Other polyphenols which inhibited the lung tumor nodule formation were rutin (71.2%), epicatechin (61%), naringin (27.2%) and naringenin (26.1%). The polyphenols which did not inhibit lung tumor nodule formation were quercetin, morin and ellagic acid. Consequent to the inhibition of the lung tumor nodules, the life span of animals treated with polyphenols was also found to be increased. Curcumin (143.85%), catechin (80.81%) and rutin (63.59%) had maximal increase in life span. The results indicate a possible use of these compounds in arresting the metastatic growth of tumor cells.
ISSN:0304-3835
1872-7980
DOI:10.1016/0304-3835(95)03887-3