Photopigments and circadian systems of vertebrates

In the retinal degeneration (rd) mouse the absence of rod cells and the progressive loss of cones does not result in a decrease in circadian phase shifting responses to light. By contrast, rd/rd mice are unable to perform simple visual tasks. In addition, rodless transgenic mice, and mice homozygous...

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Bibliographic Details
Published in:Biophysical chemistry 1995-09, Vol.56 (1), p.3-11
Main Authors: Argamaso, Sharleen M., Froehlich, Allan C., McCall, Maureen A., Nevo, Eviatar, Provencio, Ignacio, Foster, Russell G.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Circadian photoreception
Circadian Rhythm
CSF-contacting neurons
Extraretinal photoreception
Humans
Mice
Mice, Inbred Strains
Mice, Mutant Strains
Molecular Sequence Data
Opsin
Retina - physiology
Retinal degeneration
Retinal Degeneration - genetics
Retinal Degeneration - physiopathology
Retinal Pigments - chemistry
Retinal Pigments - genetics
Retinal Pigments - physiology
Retinal Rod Photoreceptor Cells - abnormalities
Rod Opsins - chemistry
Rod Opsins - genetics
Rod Opsins - physiology
Rodentia
Sequence Homology, Amino Acid
Vertebrates - physiology
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Summary:In the retinal degeneration (rd) mouse the absence of rod cells and the progressive loss of cones does not result in a decrease in circadian phase shifting responses to light. By contrast, rd/rd mice are unable to perform simple visual tasks. In addition, rodless transgenic mice, and mice homozygous for the retinal degeneration slow (rds) mutation, show unattenuated circadian responses to light. Collectively these data suggest that cone cells lacking outer segments are sufficient to maintain normal circadian responses to light, or some unidentified photoreceptor within the retina. An action spectrum for circadian responses to light in rd/rd mice, and molecular analysis of retinally degenerate mice and blind mole rat eyes, suggests the involvement of a mid-to-long wavelength sensitive cone opsin in photoentrainment. Extraocular photoreceptors of non-mammalian vertebrates are currently being analyzed in order to identify functional and evolutionary similarities between visual and non-visual photoreceptor systems.
ISSN:0301-4622
1873-4200
DOI:10.1016/0301-4622(95)00009-M