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Preliminary Studies on Antigenic Variation of Poliovirus Using Neutralizing Monoclonal Antibodies
Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, China Cross-neutralization assays were done using 85 strains of poliovirus type 1 with five groups of monoclonal antibodies. These strains were classified into 10 subgroups which had marked differences in antigenicity. Subgr...
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| Published in: | Journal of general virology 1987-04, Vol.68 (4), p.989-994 |
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| Main Authors: | , , , , , , , , |
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| container_end_page | 994 |
| container_issue | 4 |
| container_start_page | 989 |
| container_title | Journal of general virology |
| container_volume | 68 |
| creator | Ren, Guo En-Hua, Tang Hong, Wang Xiao-Feng, Yang Ming-Ying, Liu Hong-Xing, Qin Qi-Han, Li Jun-Ying, Zhuang Kai-Ming, Liu |
| description | Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, China
Cross-neutralization assays were done using 85 strains of poliovirus type 1 with five groups of monoclonal antibodies. These strains were classified into 10 subgroups which had marked differences in antigenicity. Subgroups P1-2 (28%) and P1-5 (43%) were dominant and have been epidemic in China in recent years. These two subgroups were antigenically different from the Sabin-1 strain, but according to their responses to one group of monoclonal antibodies they had antigenic epitopes in common with the Mahoney and Brunhilde strains. Similarly, 91 strains of type 3 poliovirus were classified into six subgroups with another five groups of monoclonal antibodies. The results showed that strain P3/Yunnan/2/84, which was isolated from cases of poliomyelitis in a local epidemic in the Yunnan province of China in 1984, and strain P3/Finland/23127/84, which was isolated in Finland in 1984, were both antigenically different from the Sabin-3 strain and the reference virulent strain.
Keywords: poliovirus, antigenic variation, monoclonal antibodies
Received 14 August 1986;
accepted 14 January 1987. |
| doi_str_mv | 10.1099/0022-1317-68-4-989 |
| format | article |
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Cross-neutralization assays were done using 85 strains of poliovirus type 1 with five groups of monoclonal antibodies. These strains were classified into 10 subgroups which had marked differences in antigenicity. Subgroups P1-2 (28%) and P1-5 (43%) were dominant and have been epidemic in China in recent years. These two subgroups were antigenically different from the Sabin-1 strain, but according to their responses to one group of monoclonal antibodies they had antigenic epitopes in common with the Mahoney and Brunhilde strains. Similarly, 91 strains of type 3 poliovirus were classified into six subgroups with another five groups of monoclonal antibodies. The results showed that strain P3/Yunnan/2/84, which was isolated from cases of poliomyelitis in a local epidemic in the Yunnan province of China in 1984, and strain P3/Finland/23127/84, which was isolated in Finland in 1984, were both antigenically different from the Sabin-3 strain and the reference virulent strain.
Keywords: poliovirus, antigenic variation, monoclonal antibodies
Received 14 August 1986;
accepted 14 January 1987.</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/0022-1317-68-4-989</identifier><identifier>PMID: 3033136</identifier><identifier>CODEN: JGVIAY</identifier><language>eng</language><publisher>Reading: Soc General Microbiol</publisher><subject>Animals ; Antibodies, Monoclonal - immunology ; Antigens, Viral - analysis ; Biological and medical sciences ; Epidemiology ; Fundamental and applied biological sciences. Psychology ; Mice ; Mice, Inbred BALB C ; Microbiology ; Neutralization Tests ; poliovirus ; Poliovirus - immunology ; Virology</subject><ispartof>Journal of general virology, 1987-04, Vol.68 (4), p.989-994</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-343deb215e526190fb77df20ace7a53452fca86586b596210503044ea13b9b7d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8177156$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3033136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Guo</creatorcontrib><creatorcontrib>En-Hua, Tang</creatorcontrib><creatorcontrib>Hong, Wang</creatorcontrib><creatorcontrib>Xiao-Feng, Yang</creatorcontrib><creatorcontrib>Ming-Ying, Liu</creatorcontrib><creatorcontrib>Hong-Xing, Qin</creatorcontrib><creatorcontrib>Qi-Han, Li</creatorcontrib><creatorcontrib>Jun-Ying, Zhuang</creatorcontrib><creatorcontrib>Kai-Ming, Liu</creatorcontrib><title>Preliminary Studies on Antigenic Variation of Poliovirus Using Neutralizing Monoclonal Antibodies</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, China
Cross-neutralization assays were done using 85 strains of poliovirus type 1 with five groups of monoclonal antibodies. These strains were classified into 10 subgroups which had marked differences in antigenicity. Subgroups P1-2 (28%) and P1-5 (43%) were dominant and have been epidemic in China in recent years. These two subgroups were antigenically different from the Sabin-1 strain, but according to their responses to one group of monoclonal antibodies they had antigenic epitopes in common with the Mahoney and Brunhilde strains. Similarly, 91 strains of type 3 poliovirus were classified into six subgroups with another five groups of monoclonal antibodies. The results showed that strain P3/Yunnan/2/84, which was isolated from cases of poliomyelitis in a local epidemic in the Yunnan province of China in 1984, and strain P3/Finland/23127/84, which was isolated in Finland in 1984, were both antigenically different from the Sabin-3 strain and the reference virulent strain.
Keywords: poliovirus, antigenic variation, monoclonal antibodies
Received 14 August 1986;
accepted 14 January 1987.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigens, Viral - analysis</subject><subject>Biological and medical sciences</subject><subject>Epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Neutralization Tests</subject><subject>poliovirus</subject><subject>Poliovirus - immunology</subject><subject>Virology</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAUhS0Emg5tXwCpUhYIVqH-d7KsRrQgFajUTreW4zjTixy72AkInh6HGc2WlWWf79xrnYPQG4I_ENy2lxhTWhNGVC2bmtdt075Aa8KlqGmRX6L1EThBr3P-jjHhXKgVWjHMGGFyjcxdch5GCCb9ru6nuQeXqxiqqzDBzgWw1aNJYCYob3Go7qKH-BPSnKtthrCrvrp5SsbDn-XyJYZofQzG__N3cZl2hl4Nxmd3fjhP0fb648PmU3377ebz5uq2tpzxqWac9a6jRDhBJWnx0CnVDxQb65QRjAs6WNNI0chOtJISLDDDnDtDWNd2qmen6N1-7nOKP2aXJz1Cts57E1ycs1aKt0Jw8V-wBMgbRWQB6R60Keac3KCfE4wlKE2wXgrQS756yVfLRnNdCiimi8P0uRtdf7QcEi_624NusjV-SCZYyEesIUoRsWDv99gT7J5-QXK6tDFC-UkHUZcGjgv_AlEFm8Y</recordid><startdate>19870401</startdate><enddate>19870401</enddate><creator>Ren, Guo</creator><creator>En-Hua, Tang</creator><creator>Hong, Wang</creator><creator>Xiao-Feng, Yang</creator><creator>Ming-Ying, Liu</creator><creator>Hong-Xing, Qin</creator><creator>Qi-Han, Li</creator><creator>Jun-Ying, Zhuang</creator><creator>Kai-Ming, Liu</creator><general>Soc General Microbiol</general><general>Society for General Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19870401</creationdate><title>Preliminary Studies on Antigenic Variation of Poliovirus Using Neutralizing Monoclonal Antibodies</title><author>Ren, Guo ; En-Hua, Tang ; Hong, Wang ; Xiao-Feng, Yang ; Ming-Ying, Liu ; Hong-Xing, Qin ; Qi-Han, Li ; Jun-Ying, Zhuang ; Kai-Ming, Liu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-343deb215e526190fb77df20ace7a53452fca86586b596210503044ea13b9b7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antigens, Viral - analysis</topic><topic>Biological and medical sciences</topic><topic>Epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Neutralization Tests</topic><topic>poliovirus</topic><topic>Poliovirus - immunology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ren, Guo</creatorcontrib><creatorcontrib>En-Hua, Tang</creatorcontrib><creatorcontrib>Hong, Wang</creatorcontrib><creatorcontrib>Xiao-Feng, Yang</creatorcontrib><creatorcontrib>Ming-Ying, Liu</creatorcontrib><creatorcontrib>Hong-Xing, Qin</creatorcontrib><creatorcontrib>Qi-Han, Li</creatorcontrib><creatorcontrib>Jun-Ying, Zhuang</creatorcontrib><creatorcontrib>Kai-Ming, Liu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ren, Guo</au><au>En-Hua, Tang</au><au>Hong, Wang</au><au>Xiao-Feng, Yang</au><au>Ming-Ying, Liu</au><au>Hong-Xing, Qin</au><au>Qi-Han, Li</au><au>Jun-Ying, Zhuang</au><au>Kai-Ming, Liu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preliminary Studies on Antigenic Variation of Poliovirus Using Neutralizing Monoclonal Antibodies</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1987-04-01</date><risdate>1987</risdate><volume>68</volume><issue>4</issue><spage>989</spage><epage>994</epage><pages>989-994</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><coden>JGVIAY</coden><abstract>Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, China
Cross-neutralization assays were done using 85 strains of poliovirus type 1 with five groups of monoclonal antibodies. These strains were classified into 10 subgroups which had marked differences in antigenicity. Subgroups P1-2 (28%) and P1-5 (43%) were dominant and have been epidemic in China in recent years. These two subgroups were antigenically different from the Sabin-1 strain, but according to their responses to one group of monoclonal antibodies they had antigenic epitopes in common with the Mahoney and Brunhilde strains. Similarly, 91 strains of type 3 poliovirus were classified into six subgroups with another five groups of monoclonal antibodies. The results showed that strain P3/Yunnan/2/84, which was isolated from cases of poliomyelitis in a local epidemic in the Yunnan province of China in 1984, and strain P3/Finland/23127/84, which was isolated in Finland in 1984, were both antigenically different from the Sabin-3 strain and the reference virulent strain.
Keywords: poliovirus, antigenic variation, monoclonal antibodies
Received 14 August 1986;
accepted 14 January 1987.</abstract><cop>Reading</cop><pub>Soc General Microbiol</pub><pmid>3033136</pmid><doi>10.1099/0022-1317-68-4-989</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of general virology, 1987-04, Vol.68 (4), p.989-994 |
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| language | eng |
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| source | Freely Accessible Journals |
| subjects | Animals Antibodies, Monoclonal - immunology Antigens, Viral - analysis Biological and medical sciences Epidemiology Fundamental and applied biological sciences. Psychology Mice Mice, Inbred BALB C Microbiology Neutralization Tests poliovirus Poliovirus - immunology Virology |
| title | Preliminary Studies on Antigenic Variation of Poliovirus Using Neutralizing Monoclonal Antibodies |
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