Transgenes and gene suppression: telling us something new?

Transgenes provide unique opportunities to assess the relationship between genotype and phenotype in an organism. In most cases, introduction and subsequent expression of a transgene will increase (with a sense RNA) or decrease (with an antisense RNA) the steady-state level of a specific gene produc...

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Bibliographic Details
Published in:Current opinion in cell biology 1995-06, Vol.7 (3), p.399-405
Main Authors: Dougherty, W G, Parks, T D
Format: Article
Language:English
Subjects:
Animals
Eukaryotic Cells
Humans
Models, Genetic
Prokaryotic Cells
RNA, Antisense - genetics
Suppression, Genetic
Online Access:Get full text
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Summary:Transgenes provide unique opportunities to assess the relationship between genotype and phenotype in an organism. In most cases, introduction and subsequent expression of a transgene will increase (with a sense RNA) or decrease (with an antisense RNA) the steady-state level of a specific gene product. However, a number of surprising observations have been made in the course of many transgenic studies. We develop a hypothesis that suggests that many examples of endogenous gene suppression by either antisense or sense transcripts are mediated by the same cellular mechanism.
ISSN:0955-0674
DOI:10.1016/0955-0674(95)80096-4