Environmental enrichment attenuates locomotor sensitization, but not in vitro dopamine release, induced by amphetamine

Rats were raised from weanling until young adulthood in either an enriched condition (EC) or isolated condition (IC). Following this, the locomotor and rewarding effects of amphetamine were determined using the conditioned place preference (CPP) paradigm. EC rats were more sensitive to the acute loc...

Full description

Saved in:
Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1995-06, Vol.51 (2), p.397-405
Main Authors: Bardo, M.T, Bowling, S.L, Rowlett, J.K, Manderscheid, P, Buxton, S.T, Dwoskin, L.P
Format: Article
Language:English
Subjects:
3,4-Dihydroxyphenylacetic Acid - metabolism
Amphetamine
Amphetamine - pharmacology
Animals
Biological and medical sciences
Conditioning, Operant - drug effects
Dihydroxyphenylacetic acid
Dopamine
Dopamine - metabolism
Dose-Response Relationship, Drug
Environment
Environmental enrichment
Male
Medical sciences
Motor Activity - drug effects
Neostriatum - drug effects
Neostriatum - metabolism
Neuropharmacology
Nucleus accumbens
Nucleus Accumbens - drug effects
Nucleus Accumbens - metabolism
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Sprague-Dawley
Striatum
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rats were raised from weanling until young adulthood in either an enriched condition (EC) or isolated condition (IC). Following this, the locomotor and rewarding effects of amphetamine were determined using the conditioned place preference (CPP) paradigm. EC rats were more sensitive to the acute locomotor stimulant effect and rewarding effect of amphetamine relative to IC rats. In contrast, EC rats were less sensitive than IC rats to the locomotor sensitization effect obtained across repeated amphetamine injections. To determine the effect of environmental enrichment on alteration of brain dopamine (DA) function induced by amphetamine, the effect of amphetamine on electrically evoked release of DA and dihydroxyphenylacetic acid (DOPAC) was determined in vitro using tissue slices from the nucleus accumbens and striatum of EC and IC rats. No differences between EC and IC rats in release of DA or DOPAC were evident, suggesting that the environmentally induced difference in sensitivity to the behavioral effects of amphetamine involves a neural mechanism extrinsic to the mesolimbic and nigrostriatal terminal field regions.
ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(94)00413-D