O-Carbamoylsalicylates: agents for modification of hemoglobins

To combine the attractive features of cyanate and of O-acetylsalicylate as hemoglobin-modifying agents we have prepared carbamoylsalicylate. This compound is a close analogue of aspirin and also resembles a masked cyanate. O-Carbamoylsalicylate and some related carbamates modify hemoglobin substanti...

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Bibliographic Details
Published in:Journal of medicinal chemistry 1987-05, Vol.30 (5), p.936-939
Main Authors: Parameswaran, Kumarapuram N, Shi, Guey Yeh, Klotz, Irving M
Format: Article
Language:English
Subjects:
Antisickling Agents
Carbamates - chemical synthesis
Carbamates - pharmacology
Chemical Phenomena
Chemistry
Exact sciences and technology
Hemoglobins - metabolism
Noncondensed benzenic compounds
Organic chemistry
Oxygen - metabolism
Preparations and properties
Salicylates - chemical synthesis
Salicylates - pharmacology
Structure-Activity Relationship
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Summary:To combine the attractive features of cyanate and of O-acetylsalicylate as hemoglobin-modifying agents we have prepared carbamoylsalicylate. This compound is a close analogue of aspirin and also resembles a masked cyanate. O-Carbamoylsalicylate and some related carbamates modify hemoglobin substantially, even at 5 mM concentration.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00388a034