Comparison of Two Dosage Schedules of Doxycycline in Children with Rickettsial Spotted Fever

We carried out a randomized clinical trial with oral doxycycline in children with Israel rickettsial spotted fever. Our purpose was to investigate whether an abbreviated course of therapy with this drug (until the patient was afebrile plus one day) would be as effective as a one-week regimen of ther...

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Bibliographic Details
Published in:The Journal of infectious diseases 1987-06, Vol.155 (6), p.1215-1219
Main Authors: Yagupsky, Pablo, Gross, Ellis M., Alkan, Michael, Bearman, Jacob E.
Format: Article
Language:English
Subjects:
Antibiotics
Antibodies
Bacterial diseases
Biological and medical sciences
Child
Child health services
Child, Preschool
Doxycycline - administration & dosage
Doxycycline - therapeutic use
Epidemiology
Female
Fever
Human bacterial diseases
Humans
Infant
Infectious diseases
Male
Medical sciences
Original Articles
Pediatrics
Pharmacology. Drug treatments
Prevention and actions
Public health. Hygiene
Public health. Hygiene-occupational medicine
Random Allocation
Recurrence
Rickettsia conorii
Rickettsia Infections - drug therapy
Rickettsial diseases
Rocky Mountain spotted fever
Scrub typhus
Skin, nail, hair, dermoskeleton
Specific populations (family, woman, child, elderly...)
Tropical bacterial diseases
Tropical medicine
Typhus
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Summary:We carried out a randomized clinical trial with oral doxycycline in children with Israel rickettsial spotted fever. Our purpose was to investigate whether an abbreviated course of therapy with this drug (until the patient was afebrile plus one day) would be as effective as a one-week regimen of therapy. Results with 50 pediatric patients during this three-year study indicated that the abbreviated treatment regimen was as effective. This clinical trial may serve as a model for determining shorter durations of therapy for other diseases.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/155.6.1215