Ultraviolet B irradiation increases endothelin-1 and endothelin receptor expression in cultured human keratinocytes

The effect of ultraviolet B (UVB) irradiation on endothelin-1 (ET-1) and ET receptor expression was examined using cultured normal human keratinocytes. Keratinocytes secreted ET-1 in the medium at a level of 2.1 pg/day/105 cells. UVB irradiation up to 10 mJ/cm2 increased ET-1 secretion 3-fold, and p...

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Bibliographic Details
Published in:FEBS letters 1995-09, Vol.371 (2), p.188-190
Main Authors: Tsuboi, Ryoji, Sato, Chiyo, Oshita, Yoshitami, Hama, Hiroshi, Sakurai, Takeshi, Goto, Katsutoshi, Ogawa, Hideoki
Format: Article
Language:English
Subjects:
Base Sequence
Blotting, Northern
Cells, Cultured
Electrophoresis, Agar Gel
endothelin
Endothelin receptor
Endothelin-1
Endothelins - genetics
Endothelins - metabolism
Gene Expression - radiation effects
Humans
Keratinocyte
Keratinocytes - metabolism
Molecular Sequence Data
Receptors, Endothelin - genetics
RNA, Messenger - analysis
Ultraviolet B
Ultraviolet Rays
UVB
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Summary:The effect of ultraviolet B (UVB) irradiation on endothelin-1 (ET-1) and ET receptor expression was examined using cultured normal human keratinocytes. Keratinocytes secreted ET-1 in the medium at a level of 2.1 pg/day/105 cells. UVB irradiation up to 10 mJ/cm2 increased ET-1 secretion 3-fold, and potentiated expression of mRNA for ET-1. Both ETA and ETB receptor mRNAs were detected in keratinocytes, and their expression was up-regulated by 5 mJ/cm2 UVB irradiation.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(95)00912-S