Approaches to the development of novel antihypertensive drugs: crucial role of the renal kallikrein-kinin system

The renal kallikrein-kinin system has been shown to be important in the development of hypertension, but its precise role remains to be determined. The recent use of mutant rats that are deficient in plasma kininogens and hence incapable of generating kinin in the renal tubules has facilitated eluci...

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Bibliographic Details
Published in:Trends in Pharmacological Sciences 1995-07, Vol.16 (7), p.239-246
Main Authors: Majima, M., Katori, M.
Format: Article
Language:English
Subjects:
Animals
Antihypertensive Agents - therapeutic use
Drug Design
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Kallikrein-Kinin System - physiology
Kidney - physiopathology
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Summary:The renal kallikrein-kinin system has been shown to be important in the development of hypertension, but its precise role remains to be determined. The recent use of mutant rats that are deficient in plasma kininogens and hence incapable of generating kinin in the renal tubules has facilitated elucidation of the involvement of kinin in hypertension. In this article, Masataka Majima and Makoto Katori provide evidence that the renal kallikrein-kinin system plays a crucial role in the development of hypertension and discuss a novel rationale for developing effective new antihypertensive drugs.
ISSN:0165-6147
1873-3735
DOI:10.1016/S0165-6147(00)89033-1