Loading…

Approaches to the development of novel antihypertensive drugs: crucial role of the renal kallikrein-kinin system

The renal kallikrein-kinin system has been shown to be important in the development of hypertension, but its precise role remains to be determined. The recent use of mutant rats that are deficient in plasma kininogens and hence incapable of generating kinin in the renal tubules has facilitated eluci...

Full description

Saved in:
Bibliographic Details
Published in:Trends in Pharmacological Sciences 1995-07, Vol.16 (7), p.239-246
Main Authors: Majima, M., Katori, M.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c426t-af359d1eed227a8aa1dbf9ca97241689f888a130c5c27db09f44e627b6d564933
cites cdi_FETCH-LOGICAL-c426t-af359d1eed227a8aa1dbf9ca97241689f888a130c5c27db09f44e627b6d564933
container_end_page 246
container_issue 7
container_start_page 239
container_title Trends in Pharmacological Sciences
container_volume 16
creator Majima, M.
Katori, M.
description The renal kallikrein-kinin system has been shown to be important in the development of hypertension, but its precise role remains to be determined. The recent use of mutant rats that are deficient in plasma kininogens and hence incapable of generating kinin in the renal tubules has facilitated elucidation of the involvement of kinin in hypertension. In this article, Masataka Majima and Makoto Katori provide evidence that the renal kallikrein-kinin system plays a crucial role in the development of hypertension and discuss a novel rationale for developing effective new antihypertensive drugs.
doi_str_mv 10.1016/S0165-6147(00)89033-1
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77507504</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165614700890331</els_id><sourcerecordid>77507504</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-af359d1eed227a8aa1dbf9ca97241689f888a130c5c27db09f44e627b6d564933</originalsourceid><addsrcrecordid>eNqFkEtvGyEQgFHUynUePyESp6o9bArLLrC9VFHUPCRLPbQ5IwyzMfEubIG15H9fHFu5VkKgYb6Z0XwIXVNyQwnl336Xq604bcQXQr7KjjBW0TO0pFKwignWfkDLd-QTOk_plZAC1XSBFoJzITu5RNPtNMWgzQYSzgHnDWALOxjCNILPOPTYhxJi7bPb7CeIGXxyu0LF-SV9xybOxukBxzDAgT40iODLz1YPg9tGcL7aOu88TvuUYbxEH3s9JLg6vRfo-f7nn7vHavXr4enudlWZpua50j1rO0sBbF0LLbWmdt13RneibiiXXS-l1JQR05pa2DXp-qYBXos1ty1vOsYu0Odj37Le3xlSVqNLBoZBewhzUkK0pJymgO0RNDGkFKFXU3SjjntFiTqYVm-m1UGjIkS9mVa01F2fBszrEex71Ultyf845qFsuXMQVTIOvAHrIpisbHD_mfAPNmePzQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77507504</pqid></control><display><type>article</type><title>Approaches to the development of novel antihypertensive drugs: crucial role of the renal kallikrein-kinin system</title><source>ScienceDirect Freedom Collection</source><creator>Majima, M. ; Katori, M.</creator><creatorcontrib>Majima, M. ; Katori, M.</creatorcontrib><description>The renal kallikrein-kinin system has been shown to be important in the development of hypertension, but its precise role remains to be determined. The recent use of mutant rats that are deficient in plasma kininogens and hence incapable of generating kinin in the renal tubules has facilitated elucidation of the involvement of kinin in hypertension. In this article, Masataka Majima and Makoto Katori provide evidence that the renal kallikrein-kinin system plays a crucial role in the development of hypertension and discuss a novel rationale for developing effective new antihypertensive drugs.</description><identifier>ISSN: 0165-6147</identifier><identifier>EISSN: 1873-3735</identifier><identifier>DOI: 10.1016/S0165-6147(00)89033-1</identifier><identifier>PMID: 7667898</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Antihypertensive Agents - therapeutic use ; Drug Design ; Humans ; Hypertension - drug therapy ; Hypertension - physiopathology ; Kallikrein-Kinin System - physiology ; Kidney - physiopathology</subject><ispartof>Trends in Pharmacological Sciences, 1995-07, Vol.16 (7), p.239-246</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-af359d1eed227a8aa1dbf9ca97241689f888a130c5c27db09f44e627b6d564933</citedby><cites>FETCH-LOGICAL-c426t-af359d1eed227a8aa1dbf9ca97241689f888a130c5c27db09f44e627b6d564933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>313,314,780,784,792,27922,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7667898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Majima, M.</creatorcontrib><creatorcontrib>Katori, M.</creatorcontrib><title>Approaches to the development of novel antihypertensive drugs: crucial role of the renal kallikrein-kinin system</title><title>Trends in Pharmacological Sciences</title><addtitle>Trends Pharmacol Sci</addtitle><description>The renal kallikrein-kinin system has been shown to be important in the development of hypertension, but its precise role remains to be determined. The recent use of mutant rats that are deficient in plasma kininogens and hence incapable of generating kinin in the renal tubules has facilitated elucidation of the involvement of kinin in hypertension. In this article, Masataka Majima and Makoto Katori provide evidence that the renal kallikrein-kinin system plays a crucial role in the development of hypertension and discuss a novel rationale for developing effective new antihypertensive drugs.</description><subject>Animals</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Drug Design</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Kallikrein-Kinin System - physiology</subject><subject>Kidney - physiopathology</subject><issn>0165-6147</issn><issn>1873-3735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNqFkEtvGyEQgFHUynUePyESp6o9bArLLrC9VFHUPCRLPbQ5IwyzMfEubIG15H9fHFu5VkKgYb6Z0XwIXVNyQwnl336Xq604bcQXQr7KjjBW0TO0pFKwignWfkDLd-QTOk_plZAC1XSBFoJzITu5RNPtNMWgzQYSzgHnDWALOxjCNILPOPTYhxJi7bPb7CeIGXxyu0LF-SV9xybOxukBxzDAgT40iODLz1YPg9tGcL7aOu88TvuUYbxEH3s9JLg6vRfo-f7nn7vHavXr4enudlWZpua50j1rO0sBbF0LLbWmdt13RneibiiXXS-l1JQR05pa2DXp-qYBXos1ty1vOsYu0Odj37Le3xlSVqNLBoZBewhzUkK0pJymgO0RNDGkFKFXU3SjjntFiTqYVm-m1UGjIkS9mVa01F2fBszrEex71Ultyf845qFsuXMQVTIOvAHrIpisbHD_mfAPNmePzQ</recordid><startdate>19950701</startdate><enddate>19950701</enddate><creator>Majima, M.</creator><creator>Katori, M.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950701</creationdate><title>Approaches to the development of novel antihypertensive drugs: crucial role of the renal kallikrein-kinin system</title><author>Majima, M. ; Katori, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-af359d1eed227a8aa1dbf9ca97241689f888a130c5c27db09f44e627b6d564933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Drug Design</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>Kallikrein-Kinin System - physiology</topic><topic>Kidney - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Majima, M.</creatorcontrib><creatorcontrib>Katori, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in Pharmacological Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Majima, M.</au><au>Katori, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Approaches to the development of novel antihypertensive drugs: crucial role of the renal kallikrein-kinin system</atitle><jtitle>Trends in Pharmacological Sciences</jtitle><addtitle>Trends Pharmacol Sci</addtitle><date>1995-07-01</date><risdate>1995</risdate><volume>16</volume><issue>7</issue><spage>239</spage><epage>246</epage><pages>239-246</pages><issn>0165-6147</issn><eissn>1873-3735</eissn><abstract>The renal kallikrein-kinin system has been shown to be important in the development of hypertension, but its precise role remains to be determined. The recent use of mutant rats that are deficient in plasma kininogens and hence incapable of generating kinin in the renal tubules has facilitated elucidation of the involvement of kinin in hypertension. In this article, Masataka Majima and Makoto Katori provide evidence that the renal kallikrein-kinin system plays a crucial role in the development of hypertension and discuss a novel rationale for developing effective new antihypertensive drugs.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>7667898</pmid><doi>10.1016/S0165-6147(00)89033-1</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0165-6147
ispartof Trends in Pharmacological Sciences, 1995-07, Vol.16 (7), p.239-246
issn 0165-6147
1873-3735
language eng
recordid cdi_proquest_miscellaneous_77507504
source ScienceDirect Freedom Collection
subjects Animals
Antihypertensive Agents - therapeutic use
Drug Design
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Kallikrein-Kinin System - physiology
Kidney - physiopathology
title Approaches to the development of novel antihypertensive drugs: crucial role of the renal kallikrein-kinin system
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T16%3A33%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Approaches%20to%20the%20development%20of%20novel%20antihypertensive%20drugs:%20crucial%20role%20of%20the%20renal%20kallikrein-kinin%20system&rft.jtitle=Trends%20in%20Pharmacological%20Sciences&rft.au=Majima,%20M.&rft.date=1995-07-01&rft.volume=16&rft.issue=7&rft.spage=239&rft.epage=246&rft.pages=239-246&rft.issn=0165-6147&rft.eissn=1873-3735&rft_id=info:doi/10.1016/S0165-6147(00)89033-1&rft_dat=%3Cproquest_cross%3E77507504%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c426t-af359d1eed227a8aa1dbf9ca97241689f888a130c5c27db09f44e627b6d564933%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=77507504&rft_id=info:pmid/7667898&rfr_iscdi=true