The protective effect of moclobemide against hypoxia-induced lethality in mice is not due to a decrease in body temperature

The protective effect of moclobemide, a reversible and highly selective inhibitor of monoamine oxidase-A, against hypoxia-induced lethality was investigated in the present experiment. Moclobemide showed an apparent protective potency against hypoxia and significantly prolonged the latencies for conv...

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1995-06, Vol.51 (2), p.245-247
Main Authors: Ulugol, Ahmet, Karadag, Hakan C., Dokmeci, Dikmen, Al-Khatib, Izaldin, Dokmeci, Ismet
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - therapeutic use
Benzamides - therapeutic use
Biological and medical sciences
Body temperature
Body Temperature - drug effects
Dose-Response Relationship, Drug
Hypoxia
Hypoxia - drug therapy
Hypoxia - physiopathology
Male
Medical sciences
Mice
Miscellaneous
Moclobemide
Neuropharmacology
Pharmacology. Drug treatments
Seizures - physiopathology
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Summary:The protective effect of moclobemide, a reversible and highly selective inhibitor of monoamine oxidase-A, against hypoxia-induced lethality was investigated in the present experiment. Moclobemide showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Hypothermia is known to protect animals from hypoxia. Moclobemide also decreased body temperature in mice; however, the hypothermic effect was unrelated to the antihypoxic effect. These results suggest that the protective effect of moclobemide in hypoxia is not due to a decrease in body temperature.
ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(94)00366-Q