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Increased waking after intra-accumbens injection of m-chlorophenylbiguanide: prevention with serotonin or dopamine receptor antagonists
Bilateral injection of the selective 5-HT 3 receptor agonist m-chlorophenylbiguanide (5.0–40.0 μg) into the nucleus accumbens of the rat significantly increased waking and decreased slow wave sleep. Rapid eye movement (REM) sleep remained unchanged. Pretreatment with the 5-HT 3 receptor antagonist M...
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| Published in: | European journal of pharmacology 1995-05, Vol.278 (2), p.111-115 |
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| container_end_page | 115 |
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| container_title | European journal of pharmacology |
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| creator | Ponzoni, Ana Monti, Jaime M. Jantos, Héctor Altier, Humberto Monti, Daniel |
| description | Bilateral injection of the selective 5-HT
3 receptor agonist
m-chlorophenylbiguanide (5.0–40.0 μg) into the nucleus accumbens of the rat significantly increased waking and decreased slow wave sleep. Rapid eye movement (REM) sleep remained unchanged. Pretreatment with the 5-HT
3 receptor antagonist MDL 72222 (1
aH,3
a,5
a,H-tropan-3-yl-3,5-dichloro-benzoate) (0.5 mg/kg s.c.) reversed the effects of
m-chlorophenylbiguanide (10.0–20.0 μg) on sleep and waking. Blockade of the dopamine D
1 or D
2 receptor with (+)-SCH 23390 (0.25 mg/kg s.c.) or YM-09151-2 (
cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide) (0.5 mg/kg s.c.), respectively antagonized the increase of waking and reduction of slow wave sleep induced by
m-chloro-phenylbiguanide (10.0 μg). Our results tend to indicate that the increase of wakefulness after injection of the selective 5-HT
3 receptor agonist
m-chlorophenylbiguanide into the nucleus accumbens is partly related to the release of endogenous dopamine. In addition, they suggest that concomitant stimulation of both accumbens dopamine D
1 and D
2 receptor-related mechanisms is a necessary prerequisite to increase wakefulness. |
| doi_str_mv | 10.1016/0014-2999(95)00108-W |
| format | article |
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3 receptor agonist
m-chlorophenylbiguanide (5.0–40.0 μg) into the nucleus accumbens of the rat significantly increased waking and decreased slow wave sleep. Rapid eye movement (REM) sleep remained unchanged. Pretreatment with the 5-HT
3 receptor antagonist MDL 72222 (1
aH,3
a,5
a,H-tropan-3-yl-3,5-dichloro-benzoate) (0.5 mg/kg s.c.) reversed the effects of
m-chlorophenylbiguanide (10.0–20.0 μg) on sleep and waking. Blockade of the dopamine D
1 or D
2 receptor with (+)-SCH 23390 (0.25 mg/kg s.c.) or YM-09151-2 (
cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide) (0.5 mg/kg s.c.), respectively antagonized the increase of waking and reduction of slow wave sleep induced by
m-chloro-phenylbiguanide (10.0 μg). Our results tend to indicate that the increase of wakefulness after injection of the selective 5-HT
3 receptor agonist
m-chlorophenylbiguanide into the nucleus accumbens is partly related to the release of endogenous dopamine. In addition, they suggest that concomitant stimulation of both accumbens dopamine D
1 and D
2 receptor-related mechanisms is a necessary prerequisite to increase wakefulness.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(95)00108-W</identifier><identifier>PMID: 7671995</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>(+)-SCH 23390 ; 5-HT 3 receptor ; Animals ; Benzamides - pharmacology ; Benzazepines - pharmacology ; Biguanides - administration & dosage ; Biguanides - antagonists & inhibitors ; Biguanides - pharmacology ; Biological and medical sciences ; Dopamine ; Dopamine Antagonists - pharmacology ; Injections ; m-Chlorophenylbiguanide ; Male ; MDL 72222 ; Medical sciences ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Nucleus Accumbens - physiology ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Serotonin Antagonists - pharmacology ; Serotonin Receptor Agonists - administration & dosage ; Serotonin Receptor Agonists - pharmacology ; Serotoninergic system ; Sleep ; Sleep - drug effects ; Sleep, REM - drug effects ; Tropanes - pharmacology ; Wakefulness - drug effects ; Waking ; YM-09151-2</subject><ispartof>European journal of pharmacology, 1995-05, Vol.278 (2), p.111-115</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-36abc7509f4fa974e7f621f2e49b18d5f2aa351fe1a5bba04c378bcf5575d0303</citedby><cites>FETCH-LOGICAL-c332t-36abc7509f4fa974e7f621f2e49b18d5f2aa351fe1a5bba04c378bcf5575d0303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3540390$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7671995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ponzoni, Ana</creatorcontrib><creatorcontrib>Monti, Jaime M.</creatorcontrib><creatorcontrib>Jantos, Héctor</creatorcontrib><creatorcontrib>Altier, Humberto</creatorcontrib><creatorcontrib>Monti, Daniel</creatorcontrib><title>Increased waking after intra-accumbens injection of m-chlorophenylbiguanide: prevention with serotonin or dopamine receptor antagonists</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Bilateral injection of the selective 5-HT
3 receptor agonist
m-chlorophenylbiguanide (5.0–40.0 μg) into the nucleus accumbens of the rat significantly increased waking and decreased slow wave sleep. Rapid eye movement (REM) sleep remained unchanged. Pretreatment with the 5-HT
3 receptor antagonist MDL 72222 (1
aH,3
a,5
a,H-tropan-3-yl-3,5-dichloro-benzoate) (0.5 mg/kg s.c.) reversed the effects of
m-chlorophenylbiguanide (10.0–20.0 μg) on sleep and waking. Blockade of the dopamine D
1 or D
2 receptor with (+)-SCH 23390 (0.25 mg/kg s.c.) or YM-09151-2 (
cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide) (0.5 mg/kg s.c.), respectively antagonized the increase of waking and reduction of slow wave sleep induced by
m-chloro-phenylbiguanide (10.0 μg). Our results tend to indicate that the increase of wakefulness after injection of the selective 5-HT
3 receptor agonist
m-chlorophenylbiguanide into the nucleus accumbens is partly related to the release of endogenous dopamine. In addition, they suggest that concomitant stimulation of both accumbens dopamine D
1 and D
2 receptor-related mechanisms is a necessary prerequisite to increase wakefulness.</description><subject>(+)-SCH 23390</subject><subject>5-HT 3 receptor</subject><subject>Animals</subject><subject>Benzamides - pharmacology</subject><subject>Benzazepines - pharmacology</subject><subject>Biguanides - administration & dosage</subject><subject>Biguanides - antagonists & inhibitors</subject><subject>Biguanides - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Dopamine</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>Injections</subject><subject>m-Chlorophenylbiguanide</subject><subject>Male</subject><subject>MDL 72222</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Nucleus Accumbens - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Serotonin Receptor Agonists - administration & dosage</subject><subject>Serotonin Receptor Agonists - pharmacology</subject><subject>Serotoninergic system</subject><subject>Sleep</subject><subject>Sleep - drug effects</subject><subject>Sleep, REM - drug effects</subject><subject>Tropanes - pharmacology</subject><subject>Wakefulness - drug effects</subject><subject>Waking</subject><subject>YM-09151-2</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNqFkc9u1DAQxi0EKtvCG4CUA0LlELDjeB33gIQq_lSqxAXUozVxxrsuiR1sp1WfgNfG213tEU6jme_3jez5CHnF6HtG2foDpaytG6XUuRLvSkO7-uYJWbFOqppK1jwlqyPynJymdEspFaoRJ-REriVTSqzInytvIkLCobqHX85vKrAZY-V8jlCDMcvUo0-lv0WTXfBVsNVUm-0YYpi36B_G3m0W8G7Ai2qOeIf-Ebt3eVsljCEH74orVkOYYXIeq4gG51wm4DNsipxyekGeWRgTvjzUM_Lzy-cfl9_q6-9fry4_XdeG8ybXfA29kYIq21pQskVp1w2zDbaqZ90gbAPABbPIQPQ90NZw2fXGCiHFQDnlZ-Ttfu8cw-8FU9aTSwbHETyGJWkpBaNNw_8LsnUnmOqaArZ70MSQUkSr5-gmiA-aUb0LSu9S0LsUtBL6MSh9U2yvD_uXfsLhaDokU_Q3Bx2SgdFG8MalI8ZFS7na_efjHsNytDuHUSfj0BscXDlz1kNw_37HX35Rsvs</recordid><startdate>19950515</startdate><enddate>19950515</enddate><creator>Ponzoni, Ana</creator><creator>Monti, Jaime M.</creator><creator>Jantos, Héctor</creator><creator>Altier, Humberto</creator><creator>Monti, Daniel</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19950515</creationdate><title>Increased waking after intra-accumbens injection of m-chlorophenylbiguanide: prevention with serotonin or dopamine receptor antagonists</title><author>Ponzoni, Ana ; Monti, Jaime M. ; Jantos, Héctor ; Altier, Humberto ; Monti, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-36abc7509f4fa974e7f621f2e49b18d5f2aa351fe1a5bba04c378bcf5575d0303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>(+)-SCH 23390</topic><topic>5-HT 3 receptor</topic><topic>Animals</topic><topic>Benzamides - pharmacology</topic><topic>Benzazepines - pharmacology</topic><topic>Biguanides - administration & dosage</topic><topic>Biguanides - antagonists & inhibitors</topic><topic>Biguanides - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Dopamine</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Injections</topic><topic>m-Chlorophenylbiguanide</topic><topic>Male</topic><topic>MDL 72222</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Nucleus Accumbens - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Serotonin Receptor Agonists - administration & dosage</topic><topic>Serotonin Receptor Agonists - pharmacology</topic><topic>Serotoninergic system</topic><topic>Sleep</topic><topic>Sleep - drug effects</topic><topic>Sleep, REM - drug effects</topic><topic>Tropanes - pharmacology</topic><topic>Wakefulness - drug effects</topic><topic>Waking</topic><topic>YM-09151-2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ponzoni, Ana</creatorcontrib><creatorcontrib>Monti, Jaime M.</creatorcontrib><creatorcontrib>Jantos, Héctor</creatorcontrib><creatorcontrib>Altier, Humberto</creatorcontrib><creatorcontrib>Monti, Daniel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ponzoni, Ana</au><au>Monti, Jaime M.</au><au>Jantos, Héctor</au><au>Altier, Humberto</au><au>Monti, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased waking after intra-accumbens injection of m-chlorophenylbiguanide: prevention with serotonin or dopamine receptor antagonists</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1995-05-15</date><risdate>1995</risdate><volume>278</volume><issue>2</issue><spage>111</spage><epage>115</epage><pages>111-115</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Bilateral injection of the selective 5-HT
3 receptor agonist
m-chlorophenylbiguanide (5.0–40.0 μg) into the nucleus accumbens of the rat significantly increased waking and decreased slow wave sleep. Rapid eye movement (REM) sleep remained unchanged. Pretreatment with the 5-HT
3 receptor antagonist MDL 72222 (1
aH,3
a,5
a,H-tropan-3-yl-3,5-dichloro-benzoate) (0.5 mg/kg s.c.) reversed the effects of
m-chlorophenylbiguanide (10.0–20.0 μg) on sleep and waking. Blockade of the dopamine D
1 or D
2 receptor with (+)-SCH 23390 (0.25 mg/kg s.c.) or YM-09151-2 (
cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide) (0.5 mg/kg s.c.), respectively antagonized the increase of waking and reduction of slow wave sleep induced by
m-chloro-phenylbiguanide (10.0 μg). Our results tend to indicate that the increase of wakefulness after injection of the selective 5-HT
3 receptor agonist
m-chlorophenylbiguanide into the nucleus accumbens is partly related to the release of endogenous dopamine. In addition, they suggest that concomitant stimulation of both accumbens dopamine D
1 and D
2 receptor-related mechanisms is a necessary prerequisite to increase wakefulness.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>7671995</pmid><doi>10.1016/0014-2999(95)00108-W</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1995-05, Vol.278 (2), p.111-115 |
| issn | 0014-2999 1879-0712 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77510223 |
| source | ScienceDirect Freedom Collection |
| subjects | (+)-SCH 23390 5-HT 3 receptor Animals Benzamides - pharmacology Benzazepines - pharmacology Biguanides - administration & dosage Biguanides - antagonists & inhibitors Biguanides - pharmacology Biological and medical sciences Dopamine Dopamine Antagonists - pharmacology Injections m-Chlorophenylbiguanide Male MDL 72222 Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Nucleus Accumbens - physiology Pharmacology. Drug treatments Rats Rats, Wistar Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - administration & dosage Serotonin Receptor Agonists - pharmacology Serotoninergic system Sleep Sleep - drug effects Sleep, REM - drug effects Tropanes - pharmacology Wakefulness - drug effects Waking YM-09151-2 |
| title | Increased waking after intra-accumbens injection of m-chlorophenylbiguanide: prevention with serotonin or dopamine receptor antagonists |
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