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A Novel T-Cell Differentiation Antigen Expressed in Immature Human Thymocytes and Neuroglial Cells
We report a novel human thymocyte differentiation antigen ICT-1 with a molecular weight of 49 kDa that is noncovalently associated with another 12-kDa protein. The ICT-1 antigen is expressed in 50-70% of total thymocytes, but not in resting or PHA-activated peripheral blood T-cells and bone marrow c...
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| Published in: | Cellular immunology 1995-10, Vol.165 (1), p.118-124 |
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| Main Authors: | , , , , , , , , , , , , , |
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| Language: | English |
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| container_end_page | 124 |
| container_issue | 1 |
| container_start_page | 118 |
| container_title | Cellular immunology |
| container_volume | 165 |
| creator | Bae, Young Mee Kim, Tae Jin Park, Weon Seo Chung, Doo Hyun Choi, Eun Young Lee, Geon Kook Song, Hyung Geun Kim, Chul Woo Kim, Byung Kook Ahn, Hyo Seop Park, Myoung Hee Shin, Hee Young Chi, Je Geun Park, Seong Hoe |
| description | We report a novel human thymocyte differentiation antigen ICT-1 with a molecular weight of 49 kDa that is noncovalently associated with another 12-kDa protein. The ICT-1 antigen is expressed in 50-70% of total thymocytes, but not in resting or PHA-activated peripheral blood T-cells and bone marrow cells. The thymocytes expressing ICT-1 antigen appear after the 18th week of gestation during fetal development. Since the distribution pattern of the ICT-1 antigen within thymus partly overlaps with that of the CD1 antigens, we investigated whether ICT-1 was one of the CD1 antigen family. However, the failure of anti-ICT-1 antibody to react with mouse L cells transfected with cDNA of CD1a, -b, and -c and the different histologic distribution patterns from that of CD1d strongly suggest that the anti-ICT-1 antibody recognizes an antigen distinct from CD1. Furthermore, ICT-1 is also expressed in human neuroglial cells such as oligodendroglioma, glioblastoma multiforme, Ewing's sarcoma, and cerebellar astrocyte. Hence we believe that the ICT-1 antigen may be a novel thymus-leukemia (TL) antigen or a nonclassical MHC class I antigen. |
| doi_str_mv | 10.1006/cimm.1995.1194 |
| format | article |
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The ICT-1 antigen is expressed in 50-70% of total thymocytes, but not in resting or PHA-activated peripheral blood T-cells and bone marrow cells. The thymocytes expressing ICT-1 antigen appear after the 18th week of gestation during fetal development. Since the distribution pattern of the ICT-1 antigen within thymus partly overlaps with that of the CD1 antigens, we investigated whether ICT-1 was one of the CD1 antigen family. However, the failure of anti-ICT-1 antibody to react with mouse L cells transfected with cDNA of CD1a, -b, and -c and the different histologic distribution patterns from that of CD1d strongly suggest that the anti-ICT-1 antibody recognizes an antigen distinct from CD1. Furthermore, ICT-1 is also expressed in human neuroglial cells such as oligodendroglioma, glioblastoma multiforme, Ewing's sarcoma, and cerebellar astrocyte. Hence we believe that the ICT-1 antigen may be a novel thymus-leukemia (TL) antigen or a nonclassical MHC class I antigen.</description><identifier>ISSN: 0008-8749</identifier><identifier>EISSN: 1090-2163</identifier><identifier>DOI: 10.1006/cimm.1995.1194</identifier><identifier>PMID: 7545548</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Antibodies, Monoclonal - immunology ; Antigens, CD - biosynthesis ; Antigens, CD - immunology ; Antigens, CD1 ; Antigens, Differentiation, T-Lymphocyte - chemistry ; Antigens, Differentiation, T-Lymphocyte - physiology ; Embryonic and Fetal Development - immunology ; Humans ; Immunohistochemistry ; Membrane Glycoproteins - biosynthesis ; Mice ; Mice, Inbred BALB C ; Molecular Weight ; Neuroglia - cytology ; Neuroglia - metabolism ; Phytohemagglutinins - pharmacology ; Thymus Gland - cytology ; Thymus Gland - metabolism ; Transfection - immunology ; Tumor Cells, Cultured</subject><ispartof>Cellular immunology, 1995-10, Vol.165 (1), p.118-124</ispartof><rights>1995 Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7545548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bae, Young Mee</creatorcontrib><creatorcontrib>Kim, Tae Jin</creatorcontrib><creatorcontrib>Park, Weon Seo</creatorcontrib><creatorcontrib>Chung, Doo Hyun</creatorcontrib><creatorcontrib>Choi, Eun Young</creatorcontrib><creatorcontrib>Lee, Geon Kook</creatorcontrib><creatorcontrib>Song, Hyung Geun</creatorcontrib><creatorcontrib>Kim, Chul Woo</creatorcontrib><creatorcontrib>Kim, Byung Kook</creatorcontrib><creatorcontrib>Ahn, Hyo Seop</creatorcontrib><creatorcontrib>Park, Myoung Hee</creatorcontrib><creatorcontrib>Shin, Hee Young</creatorcontrib><creatorcontrib>Chi, Je Geun</creatorcontrib><creatorcontrib>Park, Seong Hoe</creatorcontrib><title>A Novel T-Cell Differentiation Antigen Expressed in Immature Human Thymocytes and Neuroglial Cells</title><title>Cellular immunology</title><addtitle>Cell Immunol</addtitle><description>We report a novel human thymocyte differentiation antigen ICT-1 with a molecular weight of 49 kDa that is noncovalently associated with another 12-kDa protein. The ICT-1 antigen is expressed in 50-70% of total thymocytes, but not in resting or PHA-activated peripheral blood T-cells and bone marrow cells. The thymocytes expressing ICT-1 antigen appear after the 18th week of gestation during fetal development. Since the distribution pattern of the ICT-1 antigen within thymus partly overlaps with that of the CD1 antigens, we investigated whether ICT-1 was one of the CD1 antigen family. However, the failure of anti-ICT-1 antibody to react with mouse L cells transfected with cDNA of CD1a, -b, and -c and the different histologic distribution patterns from that of CD1d strongly suggest that the anti-ICT-1 antibody recognizes an antigen distinct from CD1. Furthermore, ICT-1 is also expressed in human neuroglial cells such as oligodendroglioma, glioblastoma multiforme, Ewing's sarcoma, and cerebellar astrocyte. Hence we believe that the ICT-1 antigen may be a novel thymus-leukemia (TL) antigen or a nonclassical MHC class I antigen.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigens, CD - biosynthesis</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, CD1</subject><subject>Antigens, Differentiation, T-Lymphocyte - chemistry</subject><subject>Antigens, Differentiation, T-Lymphocyte - physiology</subject><subject>Embryonic and Fetal Development - immunology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Membrane Glycoproteins - biosynthesis</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Molecular Weight</subject><subject>Neuroglia - cytology</subject><subject>Neuroglia - metabolism</subject><subject>Phytohemagglutinins - pharmacology</subject><subject>Thymus Gland - cytology</subject><subject>Thymus Gland - metabolism</subject><subject>Transfection - immunology</subject><subject>Tumor Cells, Cultured</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNqFkDtPwzAUhS0EgvJY2ZA8saVc20mcjFUpDwnBUmbLsW_AKE6KnSD670nUig0x3Sudh44-Qi4ZzBlAfmOc93NWltmcsTI9IDMGJSSc5eKQzACgSAqZlifkNMYPAMbSEo7JsczSLEuLGakW9Ln7woaukyU2Db11dY0B297p3nUtXYzfG7Z09b0JGCNa6lr66L3uh4D0YfC6pev3re_MtsdIdWvpMw6he2ucbuhUGc_JUa2biBf7e0Ze71br5UPy9HL_uFw8JUbwrE-sqa1JQWJVVRJSzjNZ5byoUGiUWghjkGnJZTlOr8FyYdCUVsh6zNWGpeKMXO96N6H7HDD2yrtoxgW6xW6ISsqMgczEv0YmIc85n4zzndGELsaAtdoE53XYKgZqoq8m-mqiryb6Y-Bq3zxUHu2vfY971IudjiOHL4dBReOwNWhdQNMr27m_qn8A2COU4Q</recordid><startdate>19951001</startdate><enddate>19951001</enddate><creator>Bae, Young Mee</creator><creator>Kim, Tae Jin</creator><creator>Park, Weon Seo</creator><creator>Chung, Doo Hyun</creator><creator>Choi, Eun Young</creator><creator>Lee, Geon Kook</creator><creator>Song, Hyung Geun</creator><creator>Kim, Chul Woo</creator><creator>Kim, Byung Kook</creator><creator>Ahn, Hyo Seop</creator><creator>Park, Myoung Hee</creator><creator>Shin, Hee Young</creator><creator>Chi, Je Geun</creator><creator>Park, Seong Hoe</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19951001</creationdate><title>A Novel T-Cell Differentiation Antigen Expressed in Immature Human Thymocytes and Neuroglial Cells</title><author>Bae, Young Mee ; Kim, Tae Jin ; Park, Weon Seo ; Chung, Doo Hyun ; Choi, Eun Young ; Lee, Geon Kook ; Song, Hyung Geun ; Kim, Chul Woo ; Kim, Byung Kook ; Ahn, Hyo Seop ; Park, Myoung Hee ; Shin, Hee Young ; Chi, Je Geun ; Park, Seong Hoe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-dcfdc407ebbb7042257b628be3ae7a33cce1a7279545f0d23cec9d37fcfdfc143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antigens, CD - biosynthesis</topic><topic>Antigens, CD - immunology</topic><topic>Antigens, CD1</topic><topic>Antigens, Differentiation, T-Lymphocyte - chemistry</topic><topic>Antigens, Differentiation, T-Lymphocyte - physiology</topic><topic>Embryonic and Fetal Development - immunology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Membrane Glycoproteins - biosynthesis</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Molecular Weight</topic><topic>Neuroglia - cytology</topic><topic>Neuroglia - metabolism</topic><topic>Phytohemagglutinins - pharmacology</topic><topic>Thymus Gland - cytology</topic><topic>Thymus Gland - metabolism</topic><topic>Transfection - immunology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bae, Young Mee</creatorcontrib><creatorcontrib>Kim, Tae Jin</creatorcontrib><creatorcontrib>Park, Weon Seo</creatorcontrib><creatorcontrib>Chung, Doo Hyun</creatorcontrib><creatorcontrib>Choi, Eun Young</creatorcontrib><creatorcontrib>Lee, Geon Kook</creatorcontrib><creatorcontrib>Song, Hyung Geun</creatorcontrib><creatorcontrib>Kim, Chul Woo</creatorcontrib><creatorcontrib>Kim, Byung Kook</creatorcontrib><creatorcontrib>Ahn, Hyo Seop</creatorcontrib><creatorcontrib>Park, Myoung Hee</creatorcontrib><creatorcontrib>Shin, Hee Young</creatorcontrib><creatorcontrib>Chi, Je Geun</creatorcontrib><creatorcontrib>Park, Seong Hoe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bae, Young Mee</au><au>Kim, Tae Jin</au><au>Park, Weon Seo</au><au>Chung, Doo Hyun</au><au>Choi, Eun Young</au><au>Lee, Geon Kook</au><au>Song, Hyung Geun</au><au>Kim, Chul Woo</au><au>Kim, Byung Kook</au><au>Ahn, Hyo Seop</au><au>Park, Myoung Hee</au><au>Shin, Hee Young</au><au>Chi, Je Geun</au><au>Park, Seong Hoe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Novel T-Cell Differentiation Antigen Expressed in Immature Human Thymocytes and Neuroglial Cells</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>1995-10-01</date><risdate>1995</risdate><volume>165</volume><issue>1</issue><spage>118</spage><epage>124</epage><pages>118-124</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><abstract>We report a novel human thymocyte differentiation antigen ICT-1 with a molecular weight of 49 kDa that is noncovalently associated with another 12-kDa protein. The ICT-1 antigen is expressed in 50-70% of total thymocytes, but not in resting or PHA-activated peripheral blood T-cells and bone marrow cells. The thymocytes expressing ICT-1 antigen appear after the 18th week of gestation during fetal development. Since the distribution pattern of the ICT-1 antigen within thymus partly overlaps with that of the CD1 antigens, we investigated whether ICT-1 was one of the CD1 antigen family. However, the failure of anti-ICT-1 antibody to react with mouse L cells transfected with cDNA of CD1a, -b, and -c and the different histologic distribution patterns from that of CD1d strongly suggest that the anti-ICT-1 antibody recognizes an antigen distinct from CD1. Furthermore, ICT-1 is also expressed in human neuroglial cells such as oligodendroglioma, glioblastoma multiforme, Ewing's sarcoma, and cerebellar astrocyte. Hence we believe that the ICT-1 antigen may be a novel thymus-leukemia (TL) antigen or a nonclassical MHC class I antigen.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>7545548</pmid><doi>10.1006/cimm.1995.1194</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0008-8749 |
| ispartof | Cellular immunology, 1995-10, Vol.165 (1), p.118-124 |
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| language | eng |
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| source | ScienceDirect Journals |
| subjects | Animals Antibodies, Monoclonal - immunology Antigens, CD - biosynthesis Antigens, CD - immunology Antigens, CD1 Antigens, Differentiation, T-Lymphocyte - chemistry Antigens, Differentiation, T-Lymphocyte - physiology Embryonic and Fetal Development - immunology Humans Immunohistochemistry Membrane Glycoproteins - biosynthesis Mice Mice, Inbred BALB C Molecular Weight Neuroglia - cytology Neuroglia - metabolism Phytohemagglutinins - pharmacology Thymus Gland - cytology Thymus Gland - metabolism Transfection - immunology Tumor Cells, Cultured |
| title | A Novel T-Cell Differentiation Antigen Expressed in Immature Human Thymocytes and Neuroglial Cells |
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