Evaluation of serum and seminal plasma markers in the diagnosis of canine prostatic disorders

• Published in: Journal of veterinary internal medicine 1995-05, Vol.9 (3), p.149-153
• Main Authors: Bell, F.W. (University of Minnesota, St. Paul, MN.), Klausner, J.S, Hayden, D.W, Lund, E.M, Liebenstein, B.B, Feeney, D.A, Johnston, S.D, Shivers, J.L, Ewing, C.M, Isaacs, W.B
• Format: Article
• Language: English
• Subjects: ACID PHOSPHATASE; Acid Phosphatase - metabolism; Analysis of Variance; Animals; ANTIGENE; ANTIGENOS; ANTIGENS; BACTERIAL PROSTATITIS; BACTERIOSE; BACTERIOSES; BACTERIOSIS; BENIGN COURSE; Biomarkers; BLOOD SERUM; CANINE PROSTATE SPECIFIC ESTERASE; CARCINOMAS; CARCINOME; CHIEN; DIAGNOSIS; DIAGNOSTIC; DIAGNOSTICO; DIFFERENTIAL DIAGNOSIS; Dog Diseases - blood; Dog Diseases - diagnosis; Dog Diseases - enzymology; Dog Diseases - microbiology; DOGS; ESTERASAS; ESTERASE; ESTERASES; Esterases - metabolism; Evaluation Studies as Topic; FOSFATASA ACIDA; Male; PATHOGENESE; PATHOGENESIS; PATOGENESIS; PERRO; PHOSPHATASE ACIDE; PROSTATA; PROSTATE; PROSTATE SPECIFIC ANTIGEN; Prostate-Specific Antigen - analysis; Prostatic Diseases - diagnosis; Prostatic Diseases - enzymology; Prostatic Diseases - microbiology; Prostatic Diseases - veterinary; Prostatic Hyperplasia - diagnosis; Prostatic Hyperplasia - veterinary; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - veterinary; SEMEN; SERUM SANGUIN; SPERME; SUERO SANGUINEO
• ISSN: 0891-6640; 1939-1676
• DOI: 10.1111/j.1939-1676.1995.tb03288.x

Serum and seminal plasma concentrations or activities of acid phosphatase (AP), prostate specific antigen (PSA), and canine prostate specific esterase (CPSE) were measured in normal dogs, dogs with benign prostatic hyperplasia (BPH), dogs with bacterial prostatitis, and dogs with prostatic carcinoma to determine if these assays would be of value in differentiating dogs with prostatic carcinoma from normal dogs, and dogs with other prostatic disorders. In addition, tissue sections of prostatic adenocarcinomas were stained with antiprostatic AP, anti‐CPSE, and anti‐PSA antibodies to determine if these would be suitable immunohistochemical markers of prostatic carcinoma. Prostate‐specific antigen was not detected in canine serum or seminal plasma. Serum and seminal AP activities did not differ significantly between normal dogs and those with prostatic diseases, or among dogs with different prostatic disorders. Serum CPSE activities were significantly higher in dogs with BPH than in normal dogs. Mean serum CPSE activities in dogs with BPH, bacterial prostatitis, and prostatic carcinoma were not significantly different from each other. Slight to moderate immunohistochemical staining of canine prostatic adenocarcinomas was noted for prostatic AP and PSA; most tumors did not stain for CPSE. These results show that proteins of prostatic origin appear in the serum of dogs as a result of prostatic pathology, especially BPH. Canine prostatic adenocarcinoma does not appear to be associated with significant increases in CPSE or AP activities, possibly because of down‐regulation of these enzymes by prostatic carcinoma cells. It is also possible that failure to detect significant differences resulted from limited statistical power for some groups and pairwise analyses because of the small number of dogs evaluated.