SODIUM THIOSULPHATE DECREASES BLOOD CYANIDE CONCENTRATIONS AFTER THE INFUSION OF SODIUM NITROPRUSSIDE

Plasma and red cell cyanide, and plasma thiocyanate, concentrations were measured in 30 patients undergoing elective nitro-prusside-induced hypotension. One randomly selected group (n = 15), who received 0.21–0.70 mg kg−1 over periods of 50– 160 min, were given a bolus of sodium thio-sulphate 10.6-3...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1987-05, Vol.59 (5), p.531-535
Main Authors: COLE, P.V., VESEY, C.J.
Format: Article
Language:English
Subjects:
Adult
Anesthetics. Neuromuscular blocking agents
Antidotes - therapeutic use
Biological and medical sciences
Cyanides - blood
Erythrocytes - analysis
Female
Ferricyanides - antagonists & inhibitors
Humans
Hypotension, Controlled
Male
Medical sciences
Neuropharmacology
Nitroprusside - antagonists & inhibitors
Pharmacology. Drug treatments
Thiocyanates - blood
Thiosulfates - therapeutic use
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Summary:Plasma and red cell cyanide, and plasma thiocyanate, concentrations were measured in 30 patients undergoing elective nitro-prusside-induced hypotension. One randomly selected group (n = 15), who received 0.21–0.70 mg kg−1 over periods of 50– 160 min, were given a bolus of sodium thio-sulphate 10.6-38.5 mg kg−1 immediately on cessation of the nitroprusside administration. The other group, who received infusions of 0.11–0.85 mg kg–1 for periods of 59—197 min, received no antidote. Cyanide concentrations, expressed as a percentage of the immediate post-infusion values, were significantly lower in the treated group in all subsequent blood samples (at 10, 30 and 60 min; plasma cyanide P < 0.05; red cell cyanide P < 0.001). Improved cyanide metabolism was further demonstrated by a sharp increase in mean plasma thiocyanate concentration (P < 0.05) in the group receiving the antidote.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/59.5.531