Effect of echinomycin on DNA methylation

Although echinomycin is reported to intercalate and to bind to DNA at CG dinucleotides, the effects of the drug on DNA methylation in vitro and in vivo are much less apparent than are the effects on DNA synthesis and cell growth.

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Bibliographic Details
Published in:FEBS letters 1987-05, Vol.215 (2), p.266-268
Main Authors: Adams, R.L.P., Rinaldi, A.
Format: Article
Language:English
Subjects:
Animals
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cell Division - drug effects
DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors
DNA - biosynthesis
DNA - metabolism
DNA methylase
DNA methylation
Echinomycin
Echinomycin - pharmacology
L Cells (Cell Line) - drug effects
Medical sciences
Methylation
Mice
Pharmacology. Drug treatments
Quinoxalines - pharmacology
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Description
Summary:Although echinomycin is reported to intercalate and to bind to DNA at CG dinucleotides, the effects of the drug on DNA methylation in vitro and in vivo are much less apparent than are the effects on DNA synthesis and cell growth.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(87)80159-X