Surface characteristics and the interaction of colloidal particles with mouse peritoneal macrophages

The effect of surface characteristics on the interaction of sterically stabilized polystyrene particles with mouse peritoneal macrophages was studied using a range of poloxamers and poloxamine as coating agents. The coated particles were characterized in terms of thickness of coating layer, surface...

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Bibliographic Details
Published in:Biomaterials 1987-03, Vol.8 (2), p.113-117
Main Authors: Illum, L., Jacobsen, L.O., Müller, R.H., Mak, E., Davis, S.S.
Format: Article
Language:English
Subjects:
Animals
Colloids
Female
In Vitro Techniques
Macrophages - physiology
Mice
Microspheres
mouse peritoneal macrophages
Phagocytosis
Poloxalene
poloxamers
poloxamine
Polymers
polystyrene particles
Polystyrenes
steric stabilization
surface characteristics
Surface Properties
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Summary:The effect of surface characteristics on the interaction of sterically stabilized polystyrene particles with mouse peritoneal macrophages was studied using a range of poloxamers and poloxamine as coating agents. The coated particles were characterized in terms of thickness of coating layer, surface charge and critical flocculation temperature. The relative phagocytic uptake was found to decrease with increasing adsorbed layer thickness i.e. longer hydrophilic polymer chains of the coating agent and consequently a greater steric stabilization effect.
ISSN:0142-9612
1878-5905
DOI:10.1016/0142-9612(87)90099-8