Centripetal Spread of Arterial Collateral Endothelial Cell Hyperplasia After Renal Artery Stenosis in the Rat

The factors responsible for collateral arterial growth after major artery occlusion remain obscure, despite their importance for tissue survival. An increase in endothelial cell labelling with tritiated thymidine, as an index of collateral arterial growth, occurs early after renal artery occlusion....

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Bibliographic Details
Published in:Circulation research 1987-03, Vol.60 (3), p.398-401
Main Authors: Hollenberg, Norman K, Odori, Teruo
Format: Article
Language:English
Subjects:
Animals
Arteries - pathology
Biological and medical sciences
Collateral Circulation
Endothelium - pathology
Hyperplasia
Male
Medical sciences
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Rats
Rats, Inbred Strains
Renal Artery Obstruction - pathology
Renovascular diseases
Space life sciences
Thymidine
Ureter - blood supply
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Summary:The factors responsible for collateral arterial growth after major artery occlusion remain obscure, despite their importance for tissue survival. An increase in endothelial cell labelling with tritiated thymidine, as an index of collateral arterial growth, occurs early after renal artery occlusion. Our working premise was that an increase in endothelial cell labelling would occur simultaneously throughout the length of the collateral arteries if biophysical factors related to blood flow were the responsible mechanism, because blood flow must be increased simultaneously throughout the length of the small, preformed collateral arterial vessels. On the other hand, if the information spread from the ischemic zone, one would anticipate centripetal spread of the endothelial cell hyperplasia in a retrograde direction from the ischemic zone. With the periureteric collateral arterial supply as the model, we performed serial studies of tritiated thymidine labelling following renal artery stenosis in the rat. As anticipated, endothelial cell labelling rose sharply within 24 to 48 hours, first evident in the area immediately adjacent to the renal hilum. Thereafter, a progressive, time-related centripetal gradient in endothelial cell tritiated thymidine labelling occurred (p
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.60.3.398