Pharmacological Characteristics of Alpha-2 Adrenergic Receptor Subtypes

The adrenergic receptor family has three main members: alpha-1, alpha-2, and beta receptor types. Each of these three types contains three or more subtypes. There are currently four pharmacological (2A, 2B, 2C, and 2D) and three molecular (or genetic) alpha-2 adrenergic subtypes (2A/D, 2B, and 2C)....

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1995-07, Vol.763 (1), p.1-7
Main Author: BYLUND, DAVID B.
Format: Article
Language:English
Subjects:
Animals
Binding Sites
Humans
Imidazoles - metabolism
Receptors, Adrenergic, alpha-2 - classification
Receptors, Adrenergic, alpha-2 - drug effects
Receptors, Adrenergic, alpha-2 - metabolism
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Summary:The adrenergic receptor family has three main members: alpha-1, alpha-2, and beta receptor types. Each of these three types contains three or more subtypes. There are currently four pharmacological (2A, 2B, 2C, and 2D) and three molecular (or genetic) alpha-2 adrenergic subtypes (2A/D, 2B, and 2C). Because different functions are likely to be mediated by different subtypes, much effort is being directed towards understanding the physiological roles of the various subtypes. However, little is currently known about the specific function mediated by the various subtypes.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1995.tb32386.x