Hydrogels in endovascular embolization. III. Radiopaque spherical particles, their preparation and properties

The synthesis and properties of spherical radiopaque hydrogel particles designed for endovascular occlusion are reported. These particles were prepared by the hydroxyl acylation of low crosslinked poly (2-hydroxyethyl methacrylate) beads with a nontoxic radiopaque compound based on triiodobenzoic ac...

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Bibliographic Details
Published in:Biomaterials 1987-03, Vol.8 (2), p.142-145
Main Authors: Horák, D., Metalová, M., Švec, F., Drobník, J., Kálal, J., Borovička, M., Adamyan, A.A., Voronkova, O.S., Gumargalieva, K.Z.
Format: Article
Language:English
Subjects:
biocompatibility
Contrast Media
Embolization, Therapeutic
embolus
endovascular occlusion
Humans
hydrogel
Hydrogel, Polyethylene Glycol Dimethacrylate
Iodine
Microspheres
poly(2-hydroxyethyl methacrylate)
Polyethylene Glycols
Polyhydroxyethyl Methacrylate
Polymers
radiopaque particles
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Summary:The synthesis and properties of spherical radiopaque hydrogel particles designed for endovascular occlusion are reported. These particles were prepared by the hydroxyl acylation of low crosslinked poly (2-hydroxyethyl methacrylate) beads with a nontoxic radiopaque compound based on triiodobenzoic acid, without affecting their properties which are advantages in medical practice. The effect of the iodine content on the size of dry and swollen particles is discussed. It has been found that an iodine content of about 25–30 wt% is desirable in order to obtain an easily recognizable X-ray image. These particles make the immediate control of embolus application easy and enable periodical inspection of the polymer to check the successful blockage of the vessel. They also open up the method of endovascular occlusion to further improvement.
ISSN:0142-9612
1878-5905
DOI:10.1016/0142-9612(87)90104-9