Plasma Cyclic Nucleotide Levels in Acute Leukemia Patients

To verify the clinical usefulness of extracellular cyclic nucleotide determination as a tumor marker, plasma cyclic AMP (cAMP) and cyclic GMP (cGMP) levels were measured in 70 normal subjects and 173 acute leukemia patients studied in different stages of their disease. Mean plasma cAMP levels were s...

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Bibliographic Details
Published in:Blood 1987-06, Vol.69 (6), p.1613-1616
Main Authors: Peracchi, Maddalena, Toschi, Vincenzo, Bamonti-Catena, Fabrizia, Lombardi, Luigia, Bareggi, Beatrice, Cortelezzi, Agostino, Colombi, Mariangela, Maiolo, Anna T., Polli, Elio E.
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cyclic AMP - blood
Cyclic GMP - blood
Female
Hematologic and hematopoietic diseases
Humans
Leukemia - blood
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Nucleotides, Cyclic - blood
Nucleotides, Cyclic - cerebrospinal fluid
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Summary:To verify the clinical usefulness of extracellular cyclic nucleotide determination as a tumor marker, plasma cyclic AMP (cAMP) and cyclic GMP (cGMP) levels were measured in 70 normal subjects and 173 acute leukemia patients studied in different stages of their disease. Mean plasma cAMP levels were similar in leukemic and normal subjects, although in 48 patients in the active stage of the disease, first diagnosis, or relapse, the cAMP values were below the normal range, and most of these patients failed to respond to chemotherapy. Plasma cGMP levels were markedly elevated in untreated patients, normalized in all patients who attained complete remission, and increased promptly to pretreatment values in patients who relapsed, suggesting that their determination may be useful to monitor the patients’ response to treatment.© 1987 by Grune & Stratton, Inc.0006-4971/87/6906-00I0$3.00/0
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V69.6.1613.1613