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Plasma Cyclic Nucleotide Levels in Acute Leukemia Patients

To verify the clinical usefulness of extracellular cyclic nucleotide determination as a tumor marker, plasma cyclic AMP (cAMP) and cyclic GMP (cGMP) levels were measured in 70 normal subjects and 173 acute leukemia patients studied in different stages of their disease. Mean plasma cAMP levels were s...

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Published in:	Blood 1987-06, Vol.69 (6), p.1613-1616
Main Authors:	Peracchi, Maddalena, Toschi, Vincenzo, Bamonti-Catena, Fabrizia, Lombardi, Luigia, Bareggi, Beatrice, Cortelezzi, Agostino, Colombi, Mariangela, Maiolo, Anna T., Polli, Elio E.
Format:	Article
Language:	English
Subjects:	Acute Disease Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Cyclic AMP - blood Cyclic GMP - blood Female Hematologic and hematopoietic diseases Humans Leukemia - blood Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Nucleotides, Cyclic - blood Nucleotides, Cyclic - cerebrospinal fluid
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container_issue	6
container_start_page	1613
container_title	Blood
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creator	Peracchi, Maddalena Toschi, Vincenzo Bamonti-Catena, Fabrizia Lombardi, Luigia Bareggi, Beatrice Cortelezzi, Agostino Colombi, Mariangela Maiolo, Anna T. Polli, Elio E.
description	To verify the clinical usefulness of extracellular cyclic nucleotide determination as a tumor marker, plasma cyclic AMP (cAMP) and cyclic GMP (cGMP) levels were measured in 70 normal subjects and 173 acute leukemia patients studied in different stages of their disease. Mean plasma cAMP levels were similar in leukemic and normal subjects, although in 48 patients in the active stage of the disease, first diagnosis, or relapse, the cAMP values were below the normal range, and most of these patients failed to respond to chemotherapy. Plasma cGMP levels were markedly elevated in untreated patients, normalized in all patients who attained complete remission, and increased promptly to pretreatment values in patients who relapsed, suggesting that their determination may be useful to monitor the patients’ response to treatment.© 1987 by Grune & Stratton, Inc.0006-4971/87/6906-00I0$3.00/0
doi_str_mv	10.1182/blood.V69.6.1613.1613
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Mean plasma cAMP levels were similar in leukemic and normal subjects, although in 48 patients in the active stage of the disease, first diagnosis, or relapse, the cAMP values were below the normal range, and most of these patients failed to respond to chemotherapy. Plasma cGMP levels were markedly elevated in untreated patients, normalized in all patients who attained complete remission, and increased promptly to pretreatment values in patients who relapsed, suggesting that their determination may be useful to monitor the patients’ response to treatment.© 1987 by Grune & Stratton, Inc.0006-4971/87/6906-00I0$3.00/0</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V69.6.1613.1613</identifier><identifier>PMID: 3034352</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Acute Disease ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Cyclic AMP - blood ; Cyclic GMP - blood ; Female ; Hematologic and hematopoietic diseases ; Humans ; Leukemia - blood ; Leukemias. Malignant lymphomas. Malignant reticulosis. 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Mean plasma cAMP levels were similar in leukemic and normal subjects, although in 48 patients in the active stage of the disease, first diagnosis, or relapse, the cAMP values were below the normal range, and most of these patients failed to respond to chemotherapy. Plasma cGMP levels were markedly elevated in untreated patients, normalized in all patients who attained complete remission, and increased promptly to pretreatment values in patients who relapsed, suggesting that their determination may be useful to monitor the patients’ response to treatment.© 1987 by Grune & Stratton, Inc.0006-4971/87/6906-00I0$3.00/0</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cyclic AMP - blood</subject><subject>Cyclic GMP - blood</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemia - blood</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. 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Mean plasma cAMP levels were similar in leukemic and normal subjects, although in 48 patients in the active stage of the disease, first diagnosis, or relapse, the cAMP values were below the normal range, and most of these patients failed to respond to chemotherapy. Plasma cGMP levels were markedly elevated in untreated patients, normalized in all patients who attained complete remission, and increased promptly to pretreatment values in patients who relapsed, suggesting that their determination may be useful to monitor the patients’ response to treatment.© 1987 by Grune & Stratton, Inc.0006-4971/87/6906-00I0$3.00/0</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>3034352</pmid><doi>10.1182/blood.V69.6.1613.1613</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
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subjects	Acute Disease Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Cyclic AMP - blood Cyclic GMP - blood Female Hematologic and hematopoietic diseases Humans Leukemia - blood Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Nucleotides, Cyclic - blood Nucleotides, Cyclic - cerebrospinal fluid
title	Plasma Cyclic Nucleotide Levels in Acute Leukemia Patients
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