Immunomodulatory action of propolis. V. Anticomplementary activity of a water-soluble derivative

The effect of a water-soluble derivative (WSD) of propolis on the classical pathway (CP) and the alternative (AP) complement activity has been investigated. The in vitro experiments show that WSD inhibits both pathways and the effect depends on the source of complement. The suppression of complement...

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Bibliographic Details
Published in:Journal of ethnopharmacology 1995-07, Vol.47 (3), p.135-143
Main Authors: Ivanovska, N.D., Dimov, V.B., Pavlova, S., Bankova, V.S., Popov, S.S.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Buffers
complement activation
Complement C3 - antagonists & inhibitors
Complement Hemolytic Activity Assay
Complement Inactivator Proteins - pharmacology
Complement inhibition
derivatives
Dose-Response Relationship, Drug
erythrocytes
Erythrocytes - drug effects
General pharmacology
Guinea Pigs
hemolysis
Hemolysis - drug effects
Humans
inhibition
Medical sciences
medicinal properties
Mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Propolis
Propolis - chemistry
Propolis - pharmacology
sheep
Solubility
Water - chemistry
Water-soluble derivative
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Summary:The effect of a water-soluble derivative (WSD) of propolis on the classical pathway (CP) and the alternative (AP) complement activity has been investigated. The in vitro experiments show that WSD inhibits both pathways and the effect depends on the source of complement. The suppression of complement-mediated haemolysis proves to be time-and temperature-related. High WSD concentrations cause direct damage of the target erythrocytes. The estimation of C3-residual activity indicates that the preparation diminishes C3 functional activity.
ISSN:0378-8741
1872-7573
DOI:10.1016/0378-8741(95)01273-G