Loading…
Natural history of asymptomatic extracranial arterial disease: results of a long-term prospective study
The natural history of asymptomatic extracranial arterial disease (EAD) was studied prospectively in 339 patients admitted for serial ultrasound Doppler examinations. Annual mortality was high at 7%, but stroke mortality was low at 0.6%: 82 patients (24%) died during the follow-up period, which last...
Saved in:
| Published in: | Brain (London, England : 1878) England : 1878), 1987-06, Vol.110 (3), p.777-791 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | 791 |
| container_issue | 3 |
| container_start_page | 777 |
| container_title | Brain (London, England : 1878) |
| container_volume | 110 |
| creator | HENNERICH, M HÜLSBÖMER, H.-B HEFTER, H LAMMERTS, D RAUTENBERG, W |
| description | The natural history of asymptomatic extracranial arterial disease (EAD) was studied prospectively in 339 patients admitted for serial ultrasound Doppler examinations. Annual mortality was high at 7%, but stroke mortality was low at 0.6%: 82 patients (24%) died during the follow-up period, which lasted up to seven years (median: 29 months), only 10 from stroke but 41 from cardiac causes. The risk of suffering a stroke without premonitory transient ischaemic attacks (TIAs) was similarly low at 0.4%. Progression of EAD was the only predictor established to indicate the individual patient's cerebrovascular prognosis among a series of criteria tested (age, sex, degree and extent of carotid and/or vertebral disease, risk factors and indicators of atherosclerosis). Deterioration of EAD was observed in 108 (36%) of 296 patients by repeated Doppler examination, 174 (59%) remained constant and 14 (5%) showed an improvement. The observed low rate of strokes without premonitory TIAs is not in favour for early carotid endarterectomy in the majority of neurologically asymptomatic patients. |
| doi_str_mv | 10.1093/brain/110.3.777 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77531949</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77531949</sourcerecordid><originalsourceid>FETCH-LOGICAL-c275t-d9c8fc716f7aa7e63b2142d2ca545d0e5320c08b8c535c837843bf6b87219aa33</originalsourceid><addsrcrecordid>eNo9kMtPwzAMhyMEGmNw5oTUA-LWLY-mSbmhiZc0wQXOlZumI6hdR5wi9t-TPbSTbfn7WdZHyDWjU0YLMas8uNWMxVFMlVInZMyynKacyfyUjCmleaoLSc_JBeI3pSwTPB-RkZCaapGNyfINwuChTb4cht5vkr5JADfdOvQdBGcS-xc8GA8rFyHwwfptUzu0gPY-8RaHNuAulrT9aplGokvWvse1NcH92gTDUG8uyVkDLdqrQ52Qz6fHj_lLunh_fp0_LFLDlQxpXRjdGMXyRgEom4uKs4zX3IDMZE2tFJwaqittpJBGC6UzUTV5pRVnBYAQE3K3vxs_-BkshrJzaGzbwsr2A5ZKScGKrIjgbA-a-Cp625Rr7zrwm5LRcqu23Kkto9pSxJiKiZvD6aHqbH3kDy7j_vawBzTQNtGZcXjEtKBcMS7-AdXGhCs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77531949</pqid></control><display><type>article</type><title>Natural history of asymptomatic extracranial arterial disease: results of a long-term prospective study</title><source>Oxford University Press Archive</source><creator>HENNERICH, M ; HÜLSBÖMER, H.-B ; HEFTER, H ; LAMMERTS, D ; RAUTENBERG, W</creator><creatorcontrib>HENNERICH, M ; HÜLSBÖMER, H.-B ; HEFTER, H ; LAMMERTS, D ; RAUTENBERG, W</creatorcontrib><description>The natural history of asymptomatic extracranial arterial disease (EAD) was studied prospectively in 339 patients admitted for serial ultrasound Doppler examinations. Annual mortality was high at 7%, but stroke mortality was low at 0.6%: 82 patients (24%) died during the follow-up period, which lasted up to seven years (median: 29 months), only 10 from stroke but 41 from cardiac causes. The risk of suffering a stroke without premonitory transient ischaemic attacks (TIAs) was similarly low at 0.4%. Progression of EAD was the only predictor established to indicate the individual patient's cerebrovascular prognosis among a series of criteria tested (age, sex, degree and extent of carotid and/or vertebral disease, risk factors and indicators of atherosclerosis). Deterioration of EAD was observed in 108 (36%) of 296 patients by repeated Doppler examination, 174 (59%) remained constant and 14 (5%) showed an improvement. The observed low rate of strokes without premonitory TIAs is not in favour for early carotid endarterectomy in the majority of neurologically asymptomatic patients.</description><identifier>ISSN: 0006-8950</identifier><identifier>EISSN: 1460-2156</identifier><identifier>DOI: 10.1093/brain/110.3.777</identifier><identifier>PMID: 3580834</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Arteriosclerosis - complications ; Arteriosclerosis - diagnosis ; Arteriosclerosis - mortality ; Biological and medical sciences ; Carotid Artery Diseases - complications ; Carotid Artery Diseases - diagnosis ; Carotid Artery Diseases - mortality ; Cerebrovascular Disorders - etiology ; Cerebrovascular Disorders - mortality ; Endarterectomy ; Female ; Humans ; Ischemic Attack, Transient - etiology ; Male ; Medical sciences ; Middle Aged ; Neurology ; Prospective Studies ; Ultrasonics ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Brain (London, England : 1878), 1987-06, Vol.110 (3), p.777-791</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8302712$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3580834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HENNERICH, M</creatorcontrib><creatorcontrib>HÜLSBÖMER, H.-B</creatorcontrib><creatorcontrib>HEFTER, H</creatorcontrib><creatorcontrib>LAMMERTS, D</creatorcontrib><creatorcontrib>RAUTENBERG, W</creatorcontrib><title>Natural history of asymptomatic extracranial arterial disease: results of a long-term prospective study</title><title>Brain (London, England : 1878)</title><addtitle>Brain</addtitle><description>The natural history of asymptomatic extracranial arterial disease (EAD) was studied prospectively in 339 patients admitted for serial ultrasound Doppler examinations. Annual mortality was high at 7%, but stroke mortality was low at 0.6%: 82 patients (24%) died during the follow-up period, which lasted up to seven years (median: 29 months), only 10 from stroke but 41 from cardiac causes. The risk of suffering a stroke without premonitory transient ischaemic attacks (TIAs) was similarly low at 0.4%. Progression of EAD was the only predictor established to indicate the individual patient's cerebrovascular prognosis among a series of criteria tested (age, sex, degree and extent of carotid and/or vertebral disease, risk factors and indicators of atherosclerosis). Deterioration of EAD was observed in 108 (36%) of 296 patients by repeated Doppler examination, 174 (59%) remained constant and 14 (5%) showed an improvement. The observed low rate of strokes without premonitory TIAs is not in favour for early carotid endarterectomy in the majority of neurologically asymptomatic patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arteriosclerosis - complications</subject><subject>Arteriosclerosis - diagnosis</subject><subject>Arteriosclerosis - mortality</subject><subject>Biological and medical sciences</subject><subject>Carotid Artery Diseases - complications</subject><subject>Carotid Artery Diseases - diagnosis</subject><subject>Carotid Artery Diseases - mortality</subject><subject>Cerebrovascular Disorders - etiology</subject><subject>Cerebrovascular Disorders - mortality</subject><subject>Endarterectomy</subject><subject>Female</subject><subject>Humans</subject><subject>Ischemic Attack, Transient - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Prospective Studies</subject><subject>Ultrasonics</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0006-8950</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><recordid>eNo9kMtPwzAMhyMEGmNw5oTUA-LWLY-mSbmhiZc0wQXOlZumI6hdR5wi9t-TPbSTbfn7WdZHyDWjU0YLMas8uNWMxVFMlVInZMyynKacyfyUjCmleaoLSc_JBeI3pSwTPB-RkZCaapGNyfINwuChTb4cht5vkr5JADfdOvQdBGcS-xc8GA8rFyHwwfptUzu0gPY-8RaHNuAulrT9aplGokvWvse1NcH92gTDUG8uyVkDLdqrQ52Qz6fHj_lLunh_fp0_LFLDlQxpXRjdGMXyRgEom4uKs4zX3IDMZE2tFJwaqittpJBGC6UzUTV5pRVnBYAQE3K3vxs_-BkshrJzaGzbwsr2A5ZKScGKrIjgbA-a-Cp625Rr7zrwm5LRcqu23Kkto9pSxJiKiZvD6aHqbH3kDy7j_vawBzTQNtGZcXjEtKBcMS7-AdXGhCs</recordid><startdate>19870601</startdate><enddate>19870601</enddate><creator>HENNERICH, M</creator><creator>HÜLSBÖMER, H.-B</creator><creator>HEFTER, H</creator><creator>LAMMERTS, D</creator><creator>RAUTENBERG, W</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870601</creationdate><title>Natural history of asymptomatic extracranial arterial disease: results of a long-term prospective study</title><author>HENNERICH, M ; HÜLSBÖMER, H.-B ; HEFTER, H ; LAMMERTS, D ; RAUTENBERG, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-d9c8fc716f7aa7e63b2142d2ca545d0e5320c08b8c535c837843bf6b87219aa33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arteriosclerosis - complications</topic><topic>Arteriosclerosis - diagnosis</topic><topic>Arteriosclerosis - mortality</topic><topic>Biological and medical sciences</topic><topic>Carotid Artery Diseases - complications</topic><topic>Carotid Artery Diseases - diagnosis</topic><topic>Carotid Artery Diseases - mortality</topic><topic>Cerebrovascular Disorders - etiology</topic><topic>Cerebrovascular Disorders - mortality</topic><topic>Endarterectomy</topic><topic>Female</topic><topic>Humans</topic><topic>Ischemic Attack, Transient - etiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Prospective Studies</topic><topic>Ultrasonics</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HENNERICH, M</creatorcontrib><creatorcontrib>HÜLSBÖMER, H.-B</creatorcontrib><creatorcontrib>HEFTER, H</creatorcontrib><creatorcontrib>LAMMERTS, D</creatorcontrib><creatorcontrib>RAUTENBERG, W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain (London, England : 1878)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HENNERICH, M</au><au>HÜLSBÖMER, H.-B</au><au>HEFTER, H</au><au>LAMMERTS, D</au><au>RAUTENBERG, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural history of asymptomatic extracranial arterial disease: results of a long-term prospective study</atitle><jtitle>Brain (London, England : 1878)</jtitle><addtitle>Brain</addtitle><date>1987-06-01</date><risdate>1987</risdate><volume>110</volume><issue>3</issue><spage>777</spage><epage>791</epage><pages>777-791</pages><issn>0006-8950</issn><eissn>1460-2156</eissn><abstract>The natural history of asymptomatic extracranial arterial disease (EAD) was studied prospectively in 339 patients admitted for serial ultrasound Doppler examinations. Annual mortality was high at 7%, but stroke mortality was low at 0.6%: 82 patients (24%) died during the follow-up period, which lasted up to seven years (median: 29 months), only 10 from stroke but 41 from cardiac causes. The risk of suffering a stroke without premonitory transient ischaemic attacks (TIAs) was similarly low at 0.4%. Progression of EAD was the only predictor established to indicate the individual patient's cerebrovascular prognosis among a series of criteria tested (age, sex, degree and extent of carotid and/or vertebral disease, risk factors and indicators of atherosclerosis). Deterioration of EAD was observed in 108 (36%) of 296 patients by repeated Doppler examination, 174 (59%) remained constant and 14 (5%) showed an improvement. The observed low rate of strokes without premonitory TIAs is not in favour for early carotid endarterectomy in the majority of neurologically asymptomatic patients.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>3580834</pmid><doi>10.1093/brain/110.3.777</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8950 |
| ispartof | Brain (London, England : 1878), 1987-06, Vol.110 (3), p.777-791 |
| issn | 0006-8950 1460-2156 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77531949 |
| source | Oxford University Press Archive |
| subjects | Adult Aged Aged, 80 and over Arteriosclerosis - complications Arteriosclerosis - diagnosis Arteriosclerosis - mortality Biological and medical sciences Carotid Artery Diseases - complications Carotid Artery Diseases - diagnosis Carotid Artery Diseases - mortality Cerebrovascular Disorders - etiology Cerebrovascular Disorders - mortality Endarterectomy Female Humans Ischemic Attack, Transient - etiology Male Medical sciences Middle Aged Neurology Prospective Studies Ultrasonics Vascular diseases and vascular malformations of the nervous system |
| title | Natural history of asymptomatic extracranial arterial disease: results of a long-term prospective study |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T12%3A33%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Natural%20history%20of%20asymptomatic%20extracranial%20arterial%20disease:%20results%20of%20a%20long-term%20prospective%20study&rft.jtitle=Brain%20(London,%20England%20:%201878)&rft.au=HENNERICH,%20M&rft.date=1987-06-01&rft.volume=110&rft.issue=3&rft.spage=777&rft.epage=791&rft.pages=777-791&rft.issn=0006-8950&rft.eissn=1460-2156&rft_id=info:doi/10.1093/brain/110.3.777&rft_dat=%3Cproquest_cross%3E77531949%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c275t-d9c8fc716f7aa7e63b2142d2ca545d0e5320c08b8c535c837843bf6b87219aa33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=77531949&rft_id=info:pmid/3580834&rfr_iscdi=true |