The effect of injection of powdered biomaterials on mouse peritoneal cell populations

The authors suggest an experimental model for the assaying, before implantation, of the tissue reaction that wear particles from artificial joints can cause in the human body. Mice were intraperitoneally injected with biomaterial powders in suspension in saline. The materials used were chromium, chr...

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Bibliographic Details
Published in:Journal of biomedical materials research 1987-04, Vol.21 (4), p.419-428
Main Authors: Pizzoferrato, A., Vespucci, A., Ciapetti, G., Stea, S., Tarabusi, C.
Format: Article
Language:English
Subjects:
Animals
Ascitic Fluid - cytology
Biocompatible Materials - pharmacology
Biological and medical sciences
Cell Count
Cell Survival
Cells, Cultured
Macrophages - drug effects
Macrophages - physiology
Medical sciences
Mice
Neutrophils - drug effects
Orthopedic surgery
Phagocytosis
Powders
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Therapeutic Irrigation
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Summary:The authors suggest an experimental model for the assaying, before implantation, of the tissue reaction that wear particles from artificial joints can cause in the human body. Mice were intraperitoneally injected with biomaterial powders in suspension in saline. The materials used were chromium, chromium oxide, nickel, nickel oxide, aluminium, alumina, alumina‐titania, cobalt, molybdenum, titanium, silver, zirconium oxide, iron oxide, and stainless steel. Peritoneal lavage was performed a week after injection. A thorough morphological and quantitative analysis of the cell suspension thus obtained was made both immediately after collection and after a 24 h culture.
ISSN:0021-9304
1097-4636
DOI:10.1002/jbm.820210403