Mapping of H2-M homolog and MOG genes in the rat MHC

Class I genes of the rat major histocompatibility complex (MHC; RT1 system) are encoded by two subregions, which are separated by regions coding for class II (RT1.B/D) and class III molecules. By convention, the RT1.A region is left of the class II region; it codes for one or very few classical clas...

Full description

Saved in:
Bibliographic Details
Published in:Immunogenetics (New York) 1995, Vol.42 (5), p.418-421
Main Authors: Lambracht, D, Prokop, C, Hedrich, H J, Fischer Lindahl, K, Wonigeit, K
Format: Article
Language:English
Subjects:
Animals
Genes, MHC Class I
Haplotypes
Histocompatibility Antigens Class I - genetics
Major Histocompatibility Complex
Myelin Proteins
Myelin-Associated Glycoprotein - genetics
Myelin-Oligodendrocyte Glycoprotein
Polymorphism, Restriction Fragment Length
Rats - genetics
Rats - immunology
Rats, Inbred Strains - genetics
Restriction Mapping
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Class I genes of the rat major histocompatibility complex (MHC; RT1 system) are encoded by two subregions, which are separated by regions coding for class II (RT1.B/D) and class III molecules. By convention, the RT1.A region is left of the class II region; it codes for one or very few classical class I molecules. The RT1. C/E region, located on the other side of the RT1 complex, contains a large number of class I genes. The internal organization of this extended class I region has not been defined in detail. It is therefore of interest that genes similar to H2-M genes, which are the most distal group of class I genes in the mouse, have been demonstrated in the rat. The rat genes similar to H2-M genes are now called RT1.M genes, and they are different from the previously defined oligomorphic class I gene RT1.M, which has been renamed RT1.R. A homolog of the H2-M3 gene has been isolated, and the sequence of RT1.M3 cDNA is 88% identical to H2-M3. RT1.M3 as well as homologs of H2-M2 and H2-M4 have been mapped with established recombinant haplotypes to the extended class I region on the RT1.C/E side of the class II/III region. We now report on a new recombinant haplotype, r38 derived from the parental strains LEW (RT1 super(l)) and BN (RT1 super(n)), in which the rat homologs of H2-M2 and H2-M4 are separated from other class I genes that differ between haplotypes l and n. This recombinant defines a new class I subregion beyond RT1.C. It also permitted mapping of the rat gene that codes for the myelin/oligodendrocyte glycoprotein (MOG) to this region of the RT1 complex.
ISSN:0093-7711
1432-1211
DOI:10.1007/BF00179405