Molecular cloning and expression of cat interferon-gamma

Interferon- gamma (IFN- gamma ) has been extensively studied in the mouse system. Produced by activated T cells and natural killer (NK) cells. This lymphokine possesses antiviral activity and exerts pleiotropic immunomodulatory activities, including. activation of macrophages and NK cells and enhanc...

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Bibliographic Details
Published in:Immunogenetics (New York) 1995, Vol.42 (5), p.440-441
Main Authors: Schijns, V E, Wierda, C M, Vahlenkamp, T W, Horzinek, M C, de Groot, R J
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Cats - genetics
DNA, Complementary - genetics
Dogs
Genes
Interferon-gamma - genetics
Molecular Sequence Data
Sequence Alignment
Sequence Homology, Amino Acid
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Summary:Interferon- gamma (IFN- gamma ) has been extensively studied in the mouse system. Produced by activated T cells and natural killer (NK) cells. This lymphokine possesses antiviral activity and exerts pleiotropic immunomodulatory activities, including. activation of macrophages and NK cells and enhancement of major histocompatibility complex class I and II expression. It is a key regulatory molecule in the T-helper cell type-1 (Th-1)-driven immune responses that are necessary for the elimination of intracellular pathogens. IFN- gamma inhibits the production of IgG1 and IgE but stimulates IgG2a production in vitro and in vivo. In mouse models recombinant IFN- gamma has adjuvant activity in malaria, Leishmania, and viral vaccines.
ISSN:0093-7711
DOI:10.1007/BF00179414